{"id":22132,"date":"2024-08-19T00:10:04","date_gmt":"2024-08-18T22:10:04","guid":{"rendered":"https:\/\/looketmedecine.fr\/?p=22132"},"modified":"2024-10-06T12:06:33","modified_gmt":"2024-10-06T10:06:33","slug":"si-la-saga-de-lah-metait-contee","status":"publish","type":"post","link":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/","title":{"rendered":"LM N\u00b02\/ 2024. ACT 1. THE SAGA OF KARL MEYER. THE DISCOVERER OF AH."},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"22132\" class=\"elementor elementor-22132\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-27a716de e-flex e-con-boxed e-con e-parent\" data-id=\"27a716de\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2d58ccea elementor-widget elementor-widget-text-editor\" data-id=\"2d58ccea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\n<p class=\"p1 wp-block-paragraph\" style=\"text-align: right;\">SI LA SAGA DE L\u2019AH <span class=\"s1\">M\u2019\u00c9TAIT CONT\u00c9E&#8230; <\/span><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-df60db5 elementor-widget elementor-widget-heading\" data-id=\"df60db5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">ACTE 1. LA SAGA DE KARL MEYER, LE D\u00c9COUVREUR DE L\u2019AH<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4529461 elementor-widget elementor-widget-image-gallery\" data-id=\"4529461\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-1' class='gallery galleryid-22132 gallery-columns-3 gallery-size-medium_large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"4529461\" data-elementor-lightbox-title=\"Karl Meyer 1\" data-elementor-lightbox-description=\"Karl Meyer 1\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxMzMsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDctMTUtYS0wMC4wOC41OC5wbmciLCJzbGlkZXNob3ciOiI0NTI5NDYxIn0%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.08.58.png'><img fetchpriority=\"high\" decoding=\"async\" width=\"398\" height=\"496\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.08.58.png\" class=\"attachment-medium_large size-medium_large\" alt=\"Karl Meyer 1\" aria-describedby=\"gallery-1-22133\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.08.58.png 398w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.08.58-241x300.png 241w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.08.58-10x12.png 10w\" sizes=\"(max-width: 398px) 100vw, 398px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-22133'>\n\t\t\t\tKarl Meyer 1\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"4529461\" data-elementor-lightbox-title=\"Karl Meyer 2\" data-elementor-lightbox-description=\"Karl Meyer 2 \" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxMzgsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDctMTUtYS0wMC4xNS40Ny5wbmciLCJzbGlkZXNob3ciOiI0NTI5NDYxIn0%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.15.47.png'><img decoding=\"async\" width=\"404\" height=\"492\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.15.47.png\" class=\"attachment-medium_large size-medium_large\" alt=\"Karl Meyer 2\" aria-describedby=\"gallery-1-22138\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.15.47.png 404w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.15.47-246x300.png 246w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.15.47-10x12.png 10w\" sizes=\"(max-width: 404px) 100vw, 404px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-22138'>\n\t\t\t\tKarl Meyer 2 \n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"4529461\" data-elementor-lightbox-title=\"Karl Meyer 3\" data-elementor-lightbox-description=\"Karl Meyer 3 \" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxNDAsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDctMTUtYS0wMC4xNS41NS5wbmciLCJzbGlkZXNob3ciOiI0NTI5NDYxIn0%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.15.55.png'><img decoding=\"async\" width=\"348\" height=\"496\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.15.55.png\" class=\"attachment-medium_large size-medium_large\" alt=\"Karl Meyer 3\" aria-describedby=\"gallery-1-22140\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.15.55.png 348w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.15.55-210x300.png 210w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.15.55-8x12.png 8w\" sizes=\"(max-width: 348px) 100vw, 348px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-22140'>\n\t\t\t\tKarl Meyer 3 \n\t\t\t\t<\/figcaption><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ba4851 elementor-widget elementor-widget-image-gallery\" data-id=\"8ba4851\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-2' class='gallery galleryid-22132 gallery-columns-2 gallery-size-full'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"8ba4851\" data-elementor-lightbox-title=\"article princeps AH\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxNDUsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL2FydGljbGUtcHJpbmNlcHMtQUgtLmpwZyIsInNsaWRlc2hvdyI6IjhiYTQ4NTEifQ%3D%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/article-princeps-AH-.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"641\" height=\"543\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/article-princeps-AH-.jpg\" class=\"attachment-full size-full\" alt=\"article-princeps-AH\" aria-describedby=\"gallery-2-22145\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/article-princeps-AH-.jpg 641w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/article-princeps-AH--300x254.jpg 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/article-princeps-AH--14x12.jpg 14w\" sizes=\"(max-width: 641px) 100vw, 641px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-2-22145'>\n\t\t\t\tarticle-princeps-AH\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"8ba4851\" data-elementor-lightbox-title=\"MOLECULE AH KARL MEYER\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxNDYsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL01PTEVDVUxFLUFILUtBUkwtTUVZRVItLmpwZyIsInNsaWRlc2hvdyI6IjhiYTQ4NTEifQ%3D%3D\" data-elementor-lightbox-description=\"MOLECULE-AH-KARL-MEYER\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/MOLECULE-AH-KARL-MEYER-.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"513\" height=\"596\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/MOLECULE-AH-KARL-MEYER-.jpg\" class=\"attachment-full size-full\" alt=\"MOLECULE-AH-KARL-MEYER\" aria-describedby=\"gallery-2-22146\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/MOLECULE-AH-KARL-MEYER-.jpg 513w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/MOLECULE-AH-KARL-MEYER--258x300.jpg 258w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/MOLECULE-AH-KARL-MEYER--10x12.jpg 10w\" sizes=\"(max-width: 513px) 100vw, 513px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-2-22146'>\n\t\t\t\tMOLECULE-AH-KARL-MEYER\n\t\t\t\t<\/figcaption><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c49a92 elementor-widget elementor-widget-heading\" data-id=\"4c49a92\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. L\u2019\u00c9POP\u00c9E D\u2019UN JEUNE M\u00c9DECIN ET BIOCHIMISTE, JUIF ALLEMAND,                      QUI \u00c9MIGRE AUX USA EN 1930 POUR FUIR LE R\u00c9GIME NAZI. <br><br>IL VA D\u00c9COUVRIR L\u2019ACIDE HYALURONIQUE. <br><br>UNE LONGUE HISTOIRE QUI COMMENCE IL Y A 120 ANS....<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-00e401a elementor-widget elementor-widget-image-gallery\" data-id=\"00e401a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-3' class='gallery galleryid-22132 gallery-columns-2 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"00e401a\" data-elementor-lightbox-title=\"Capture d\u2019e\u0301cran 2024-07-15 a\u0300 00.28.45\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxNDgsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDctMTUtYS0wMC4yOC40NS5wbmciLCJzbGlkZXNob3ciOiIwMGU0MDFhIn0%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.28.45.png'><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"536\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.28.45-1024x686.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.28.45-1024x686.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.28.45-300x201.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.28.45-768x514.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.28.45-18x12.png 18w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.28.45.png 1036w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"00e401a\" data-elementor-lightbox-title=\"Capture d\u2019e\u0301cran 2024-07-15 a\u0300 00.29.11\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxNDcsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDctMTUtYS0wMC4yOS4xMS5wbmciLCJzbGlkZXNob3ciOiIwMGU0MDFhIn0%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.11.png'><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"560\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.11.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.11.png 1014w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.11-300x210.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.11-768x538.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.11-18x12.png 18w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d223c5a elementor-widget elementor-widget-text-editor\" data-id=\"d223c5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"p1\"><span style=\"color: #0000ff;\">En 1917, \u00e0 l\u2019\u00e2ge de 17 ans, Karl Meyer est incorpor\u00e9 dans l\u2019arm\u00e9e allemande et sert la derni\u00e8re ann\u00e9e de la guerre sur le front occidental, dans les Flandres et le centre de la France.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">Il est fort possible que les exp\u00e9riences qu\u2019il a v\u00e9cues pendant ce conflit cataclysmique aient jou\u00e9 un r\u00f4le important dans sa d\u00e9cision de r\u00e9orienter ses \u00e9tudes classiques vers la m\u00e9decine.<\/span><\/h4>\n<h4 class=\"p3\"><span style=\"color: #0000ff;\"><i>\u00ab Je suis n\u00e9 le 4 septembre 1899 \u00e0 Kerpen, Cologne, Allemagne. Je suis le quatri\u00e8me enfant et le seul fils de Ludwig et Ida Meyer. Kerpen \u00e9tait alors un village d\u2019environ 4 000 habitants. <\/i><\/span><\/h4>\n<h4 class=\"p4\"><span style=\"color: #0000ff;\"><i>J\u2019ai grandi dans un foyer rural simple o\u00f9, d\u00e8s ma plus tendre enfance, j\u2019avais, comme le reste de la famille, mes t\u00e2ches assign\u00e9es dans la maison, le jardin et les champs. <\/i><\/span><\/h4>\n<h4 class=\"p4\"><span style=\"color: #0000ff;\"><i>\u00c0 l\u2019\u00e2ge de 4 ans, j\u2019ai appris \u00e0 lire pour la premi\u00e8re fois en h\u00e9breu. \u00c0 5 ans et demi, j\u2019ai rejoint l\u2019\u00e9cole juive de Kerpen et \u00e0 10 ans, j\u2019ai \u00e9t\u00e9 transf\u00e9r\u00e9 \u00e0 la H\u00f6here Schole de Kerpen. Il s\u2019agissait d\u2019un gymnase priv\u00e9 catholique qui mettait presque exclusivement l\u2019accent sur le latin et le grec. (Karl Meyer, Acad\u00e9mie nationale des sciences, 1967).\u00bb <\/i><\/span><\/h4>\n<h4 class=\"p5\">\u00a0<\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7c5cb6 elementor-widget elementor-widget-image\" data-id=\"f7c5cb6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1766\" height=\"888\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.24.png\" class=\"attachment-full size-full wp-image-22149\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.24.png 1766w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.24-300x151.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.24-1024x515.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.24-768x386.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.24-1536x772.png 1536w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.24-18x9.png 18w\" sizes=\"(max-width: 1766px) 100vw, 1766px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a869d14 elementor-widget elementor-widget-text-editor\" data-id=\"a869d14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"p5\"><span style=\"color: #0000ff;\">Apr\u00e8s sa d\u00e9mobilisation, Karl Meyer entre \u00e0 l\u2019\u00e9cole de m\u00e9decine et obtient son doctorat en 1924 \u00e0 l\u2019universit\u00e9 de Cologne.<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #0000ff;\">Il travaille comme clinicien pour la derni\u00e8re fois au cours de ses derniers mois d\u2019internat \u00e0 Cologne, dans la division des maladies infectieuses, o\u00f9 il traite des femmes en phase terminale de tuberculose et o\u00f9 il court un risque consid\u00e9rable de contracter cette maladie, \u00e0 l\u2019\u00e9poque redoutable.<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #0000ff;\">The D<span class=\"s1\">r <\/span>Meyer se rend ensuite \u00e0 Berlin pour suivre un cours d\u2019un an en chimie m\u00e9dicale. Il y rencontre plusieurs jeunes scientifiques prometteurs qui entament une brillante carri\u00e8re, notamment Hans Krebs, Fritz Lipmann et Ernst Chain.<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #0000ff;\">\u00c0 ce tournant majeur de sa vie, Meyer d\u00e9cide de poursuivre sa formation en chimie et s\u2019inscrit finalement comme \u00e9tudiant dipl\u00f4m\u00e9 dans le laboratoire d\u2019Otto Meyerhof \u00e0 l\u2019Institut Kaiser-Wilhelm.<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #0000ff;\">Son travail de th\u00e8se sur la formation enzymatique de l\u2019acide lactique dans le tissu musculaire et dans la fermentation de la levure a montr\u00e9 que la r\u00e9action n\u00e9cessitait un coenzyme thermostable, identifi\u00e9 plus tard comme \u00e9tant l\u2019ADP, et l\u2019a lanc\u00e9 sur la voie de sa carri\u00e8re de chercheur.<\/span><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a7c9ee7 elementor-widget elementor-widget-image\" data-id=\"a7c9ee7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1364\" height=\"1230\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.49.png\" class=\"attachment-full size-full wp-image-22150\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.49.png 1364w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.49-300x271.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.49-1024x923.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.49-768x693.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.29.49-13x12.png 13w\" sizes=\"(max-width: 1364px) 100vw, 1364px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d139d13 elementor-widget elementor-widget-heading\" data-id=\"d139d13\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. SUIVONS PAR BERLIN, ZURICH, BERKELEY, NEW YORK\u2026 <br><br>LE LONG CHEMIN DE CE JEUNE BIOCHIMISTE PROMETTEUR QUI VA FINALEMENT LE CONDUIRE EN 1933 ....<br><br>\u00c0 UN POSTE DE PROFESSEUR ASSISTANT AU D\u00c9PARTEMENT D\u2019OPHTALMOLOGIE DE L\u2019UNIVERSIT\u00c9 DE COLUMBIA \u00c0 NEW YORK<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fbac020 elementor-widget elementor-widget-text-editor\" data-id=\"fbac020\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"p1\"><span style=\"text-decoration: underline;\"><span style=\"color: #0000ff;\"><em>Et c\u2019est cette nomination de circonstance, en ophtalmologie, qui va le conduire \u00e0 p\u00e9n\u00e9trer dans le domaine de la biochimie des tissus oculaires, de l\u2019humeur vitr\u00e9e du boeuf : il va y d\u00e9couvrir l\u2019hyaluronane, autrement dit l\u2019acide hyaluronique.<\/em><\/span><\/span><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fc5085b elementor-widget elementor-widget-text-editor\" data-id=\"fc5085b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol>\n<li>\n<h4><span style=\"color: #0000ff;\">En 1927, le D<span class=\"s1\">r <\/span>Meyer a obtenu son doctorat en chimie \u00e0 Berlin et a re\u00e7u une bourse de la Fondation Rockefeller pour \u00e9tudier avec le professeur Kuhn \u00e0 l\u2019Institut f\u00e9d\u00e9ral suisse de technologie de Zurich ; il a pass\u00e9 pr\u00e8s de trois ans \u00e0 l\u2019institut \u00e0 \u00e9tudier la capacit\u00e9 des complexes h\u00e9miques \u00e0 catalyser l\u2019oxydation des compos\u00e9s insatur\u00e9s.<\/span><\/h4>\n<\/li>\n<li>\n<h4><span style=\"color: #0000ff;\"><span class=\"s2\">En 1930, il accepte l\u2019offre de Herbert Evans <\/span>de travailler sur les hormones de l\u2019ant\u00e9hypophyse en tant que professeur assistant \u00e0 l\u2019Universit\u00e9 de Californie, Berkeley. En avril, il embarque avec sa nouvelle \u00e9pouse, Martha, rencontr\u00e9e \u00e0 Zurich, sur un paquebot \u00e0 destination de New York.<\/span><\/h4>\n<\/li>\n<li class=\"p4\">\n<h4><span style=\"color: #0000ff;\">\u00c0 Ellis Island, ils d\u00e9couvrent qu\u2019il a re\u00e7u un visa de touriste plut\u00f4t qu\u2019un permis de travail. Un agent d\u2019immigration compr\u00e9hensif leur sugg\u00e8re de passer de bonnes vacances sur la route de la Californie et lui demande de se rendre dans un consulat am\u00e9ricain au Mexique ou au Canada pour obtenir les documents n\u00e9cessaires.<\/span><\/h4>\n<\/li>\n<li class=\"p4\">\n<h4><span style=\"color: #0000ff;\">Apr\u00e8s deux jours difficiles \u00e0 Tijuana, Meyer y est parvenu et a pu accepter son poste \u00e0 l\u2019universit\u00e9 de Californie \u00e0 Berkeley.<\/span><\/h4>\n<\/li>\n<li>\n<h4><span style=\"color: #0000ff;\">The D<span class=\"s1\">r <\/span>Meyer a assist\u00e9 \u00e0 une conf\u00e9rence en Europe en 1932 et s\u2019est trouv\u00e9 confront\u00e9 \u00e0 un autre obstacle majeur. Il y <span class=\"s2\">apprend, \u00e0 sa grande consternation, qu\u2019Evans met fin \u00e0 son <\/span>poste \u00e0 l\u2019Universit\u00e9 de Californie \u00e0 Berkeley lui conseillant de retourner en Allemagne, en pleine ascension du r\u00e9gime nazi avec la mont\u00e9e des p\u00e9rils pour les juifs.<\/span><\/h4>\n<\/li>\n<li class=\"p6\">\n<h4><span style=\"color: #0000ff;\">Karl Meyer d\u00e9cide de retourner aux USA pour tenter sa chance. Et c\u2019est Hans Clarke de l\u2019Universit\u00e9 Columbia de New York qui va le sauver. Apr\u00e8s son arriv\u00e9e \u00e0 New York, Hans Clarke lui fournit une bourse int\u00e9rimaire jusqu\u2019\u00e0 ce qu\u2019il obtienne un poste de professeur assistant au d\u00e9partement d\u2019ophtalmologie de l\u2019Universit\u00e9 Columbia en 1933.<\/span><\/h4>\n<\/li>\n<\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-385b372 elementor-widget elementor-widget-image-gallery\" data-id=\"385b372\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-4' class='gallery galleryid-22132 gallery-columns-2 gallery-size-full'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"385b372\" data-elementor-lightbox-title=\"Capture d\u2019e\u0301cran 2024-07-15 a\u0300 00.30.00\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxNTcsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDctMTUtYS0wMC4zMC4wMC5wbmciLCJzbGlkZXNob3ciOiIzODViMzcyIn0%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.00.png'><img loading=\"lazy\" decoding=\"async\" width=\"1126\" height=\"472\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.00.png\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.00.png 1126w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.00-300x126.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.00-1024x429.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.00-768x322.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.00-18x8.png 18w\" sizes=\"(max-width: 1126px) 100vw, 1126px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"385b372\" data-elementor-lightbox-title=\"Capture d\u2019e\u0301cran 2024-07-15 a\u0300 00.30.25\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxNTksInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDctMTUtYS0wMC4zMC4yNS5wbmciLCJzbGlkZXNob3ciOiIzODViMzcyIn0%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.25.png'><img loading=\"lazy\" decoding=\"async\" width=\"1808\" height=\"856\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.25.png\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.25.png 1808w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.25-300x142.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.25-1024x485.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.25-768x364.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.25-1536x727.png 1536w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.25-18x9.png 18w\" sizes=\"(max-width: 1808px) 100vw, 1808px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"385b372\" data-elementor-lightbox-title=\"Capture d\u2019e\u0301cran 2024-07-15 a\u0300 00.48.59\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxNjEsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDctMTUtYS0wMC40OC41OS5wbmciLCJzbGlkZXNob3ciOiIzODViMzcyIn0%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.48.59.png'><img loading=\"lazy\" decoding=\"async\" width=\"482\" height=\"294\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.48.59.png\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-4-22161\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.48.59.png 482w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.48.59-300x183.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.48.59-18x12.png 18w\" sizes=\"(max-width: 482px) 100vw, 482px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-4-22161'>\n\t\t\t\tL\u2019Universit\u00e9 Columbia de New York.\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"385b372\" data-elementor-lightbox-title=\"Capture d\u2019e\u0301cran 2024-07-15 a\u0300 00.30.09\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIxNjIsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDdcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDctMTUtYS0wMC4zMC4wOS0xLnBuZyIsInNsaWRlc2hvdyI6IjM4NWIzNzIifQ%3D%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.09-1.png'><img loading=\"lazy\" decoding=\"async\" width=\"458\" height=\"674\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.09-1.png\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.09-1.png 458w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.09-1-204x300.png 204w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.09-1-8x12.png 8w\" sizes=\"(max-width: 458px) 100vw, 458px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6320890 elementor-widget elementor-widget-heading\" data-id=\"6320890\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3 .LA D\u00c9COUVERTE DE L\u2019HYALURONANE 1934<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3db144 elementor-widget elementor-widget-text-editor\" data-id=\"c3db144\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"p1\"><span style=\"color: #800080;\"><i>Les recherches pr\u00e9liminaires avant les travaux de Karl Meyer <\/i><\/span><\/h2>\n<h4 class=\"p1\"><span style=\"color: #800080;\">Press\u00e9 de travailler sur des tissus pertinents, Meyer entreprend des \u00e9tudes sur le lysozyme dans les larmes et il cherche une autre source de substrat muco\u00efde pour l\u2019enzyme.<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #800080;\">\u00c0 l\u2019\u00e9poque o\u00f9 Karl Meyer commen\u00e7ait ses recherches pionni\u00e8res sur l\u2019hyaluronane, des travaux pertinents ant\u00e9rieurs avaient \u00e9t\u00e9 r\u00e9alis\u00e9s dont il connaissait sans doute l\u2019existence et qu\u2019il jugeait utiles pour replacer son travail dans son contexte appropri\u00e9.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #800080;\">Le chimiste fran\u00e7ais Portes a rapport\u00e9 en 1880 qu\u2019une mucine isol\u00e9e du corps vitr\u00e9 diff\u00e9rait des pr\u00e9parations similaires provenant de la corn\u00e9e et du cartilage par son comportement dans les solutions acides, et il l\u2019a appel\u00e9 un \u00ab hyalomuco\u00efde \u00bb.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #800080;\">Un pr\u00e9curseur de l\u2019acide hyaluronique, nom invent\u00e9 par Karl Meyer dans l\u2019article de 1934 de Meyer et Palmer qui a \u00e9t\u00e9 pr\u00e9sent\u00e9 dans le <span class=\"s1\"><i>Journal of Biological Chemistry Classic <\/i><\/span>(McDonald et Hascall, 2002).<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #800080;\">Des travaux ult\u00e9rieurs r\u00e9alis\u00e9 par Karl Morner en Su\u00e8de en 1884 confirm\u00e8rent les r\u00e9sultats de Portes et montr\u00e8rent que l\u2019hyalomuco\u00efde contenait consid\u00e9rablement moins de soufre que les muco\u00efdes isol\u00e9s de deux autres tissus.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #800080;\">En 1918, le laboratoire de PAT Levene, un groupe dominant \u00e0 l\u2019\u00e9poque dans la chimie des glucides a isol\u00e9 un polysaccharide contenant de la glucosamine, de l\u2019acide glucuronique et du sulfate qu\u2019ils ont appel\u00e9 \u00abacide sulfurique mucoitine\u00bb. Il s\u2019agissait probablement principalement d\u2019hyaluronane, bien que, Meyer ait montr\u00e9 plus tard que l\u2019hyaluronane ne contient aucun groupe sulfate<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #800080;\">Ces travaux ant\u00e9rieurs ont pr\u00e9par\u00e9 le terrain pour l\u2019article de 1934.Karl Meyer consid\u00e8re l\u2019humeur vitr\u00e9e, tr\u00e8s visqueuse, comme un candidat probable. La d\u00e9couverte de l\u2019hyaluronane va suivre rapidement :<\/span><\/h4>\n<h2><span style=\"color: #0000ff;\"><i>\u00ab Dans l\u2019humeur vitr\u00e9e des yeux de bovins, on a obtenu un acide polysaccharidique de poids mol\u00e9culaire \u00e9lev\u00e9&#8230;\u00a0<\/i><\/span><i style=\"color: #0000ff; font-family: inherit; font-size: 2rem; text-align: var(--text-align);\">Comme constituants, on a reconnu un acide uronique, un sucre amin\u00e9&#8230;. Il semble s\u2019agir d\u2019une substance unique chez les animaux sup\u00e9rieurs, que l\u2019on peut comparer \u00e0 certains polysaccharides sp\u00e9cifiques des bact\u00e9ries.\u00a0\u00a0<\/i><i style=\"color: #0000ff; font-family: inherit; font-size: 2rem; text-align: var(--text-align);\">Nous proposons, par commodit\u00e9, le nom d\u2019\u00ab acide hyaluronique \u00bb, qui vient de hyalo\u00efde (vitreux) + acide uronique (1934) \u00bb.<\/i><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-96dc072 elementor-widget elementor-widget-heading\" data-id=\"96dc072\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. LA SAGA DE KARL MEYER VA SE POURSUIVRE EN ALLANT DE LA M\u00c9CONNAISSANCE \u00c0 LA RECONNAISSANCE TARDIVE PAR LA COMMUNAUT\u00c9 SCIENTIFIQUE.<br><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89d765f elementor-widget elementor-widget-heading\" data-id=\"89d765f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">MAIS LE PREMIER MOTEUR DE LA SUITE DU D\u00c9VELOPPEMENT DES CONNAISSANCES SUR L\u2019AH REPOSE SUR LA T\u00c9NACIT\u00c9 DE KARL MEYER LUI-M\u00caME. IL A POURSUIVI SES TRAVAUX DANS UNE GRANDE INDIFF\u00c9RENCE.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-385f40e elementor-widget elementor-widget-text-editor\" data-id=\"385f40e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"p1\"><span style=\"color: #800080;\">\u00ab \u00c0 mon avis, les mucopolysaccharides ne seront jamais un domaine tr\u00e8s populaire en biochimie, <span class=\"s1\">mais ils ne seront probablement pas rel\u00e9gu\u00e9s \u00e0 l\u2019insignifiance et au m\u00e9pris dans lesquels ils \u00e9taient <\/span>tenus il n\u2019y a pas si longtemps \u00bb (Karl Meyer, Pr\u00e9sident, American Society of Biological Chemists Symposium on Acid Mucopolysaccharides of Animal Origin, 1958).<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">Il faudra attendre pr\u00e8s de 25 ans pour que ses \u00e9tudes relient correctement les deux sucres identifi\u00e9s <span class=\"s2\">dans l\u2019article classique de 1934 pour former le disaccharide hyaluronane. En cours de route, une <\/span>s\u00e9rie d\u2019\u00e9tudes classiques avec des hyaluronidases s\u2019est av\u00e9r\u00e9e essentielle pour d\u00e9finir la structure.<\/span><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2dde834 elementor-widget elementor-widget-image\" data-id=\"2dde834\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"2042\" height=\"1424\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.46.png\" class=\"attachment-full size-full wp-image-22172\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.46.png 2042w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.46-300x209.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.46-1024x714.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.46-768x536.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.46-1536x1071.png 1536w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.30.46-18x12.png 18w\" sizes=\"(max-width: 2042px) 100vw, 2042px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cbe34d3 elementor-widget elementor-widget-text-editor\" data-id=\"cbe34d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"p3\"><span style=\"color: #0000ff;\">Les r\u00e9sultats exp\u00e9rimentaux d\u00e9crits <span class=\"s1\">dans la figure 1 (en haut) <\/span>ont conduit \u00e0 l\u2019interpr\u00e9tation correcte que les digestions limites par la hyaluronidase testiculaire produisaient principalement des t\u00e9trasaccharides qui pouvaient \u00eatre cliv\u00e9s en disaccharides plus petits par la hyaluronidase bact\u00e9rienne (Rapport et al., 1951).<\/span><\/h4>\n<h4 class=\"p3\"><span style=\"color: #0000ff;\">La structure du disaccharide <span class=\"s1\">(figure 1, en bas) <\/span>a \u00e9t\u00e9 d\u00e9finie dans un petit article publi\u00e9 dans \u00ab Nature \u00bb en 1954, indiquant clairement que les enzymes bact\u00e9riennes sont des \u00e9liminases (1954).<\/span><\/h4>\n<h4 class=\"p3\"><span style=\"color: #0000ff;\">Ceux d\u2019entre nous qui ont travaill\u00e9 dur pour isoler des oligosaccharides de hyaluronane de tailles d\u00e9finies ne peuvent qu\u2019admirer le <span class=\"s1\">profil de la figure 2<\/span>, qui montre la r\u00e9solution de base jusqu\u2019\u00e0 18 mers dans les fractions d\u2019une colonne d\u2019\u00e9change d\u2019ions, recueillies en 1954 sans l\u2019aide d\u2019un collecteur de fractions (1954).<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #800080;\">\u00c0 la fin des ann\u00e9es 1950, les travaux de Meyer \u00e9taient de plus en plus reconnus, ce qui a sans <span class=\"s1\">doute suscit\u00e9 le commentaire suivant : <\/span><\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">\u00ab Je pense que les mucopolysaccharides ne seront jamais un domaine tr\u00e8s populaire en biochimie, <span class=\"s2\">mais ils ne seront probablement pas rel\u00e9gu\u00e9s \u00e0 l\u2019insignifiance et au m\u00e9pris dans lesquels ils \u00e9taient <\/span>tenus il n\u2019y a pas si longtemps \u00bb <span style=\"color: #800080;\">(Karl Meyer, pr\u00e9sident, American Society of Biological Chemists Symposium on Acid Mucopolysaccharides of Animal Origin, 1958).<\/span><\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">L\u2019hyaluronane \u00e9tait son premier amour, mais le D<span class=\"s3\">r <\/span>Meyer n\u2019a pas ignor\u00e9 les autres glycosaminoglycanes. <\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">Les premiers travaux publi\u00e9s en 1937 utilisaient des solutions de chlorure de calcium pour extraire le sulfate de chondro\u00eftine du cartilage. <\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">Il a \u00e9t\u00e9 observ\u00e9 que le sel d\u2019acide chondro\u00eftine sulfurique de la g\u00e9latine \u00e9tait soluble dans une solution concentr\u00e9e de chlorure de calcium, de baryum ou de strontium. Cette observation a \u00e9t\u00e9 utilis\u00e9e pour l\u2019extraction de l\u2019acide chondro\u00eftine sulfurique du cartilage en solution neutre.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">Jusqu\u2019\u00e0 pr\u00e9sent, l\u2019extraction avec un alcali fort a \u00e9t\u00e9 utilis\u00e9e pour la pr\u00e9paration de l\u2019acide chondro\u00eftinsulfurique. <\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">Comme le traitement avec un alcali peut facilement conduire \u00e0 une d\u00e9composition, la pr\u00e9sente m\u00e9thode d\u2019extraction par une solution neutre de CaCl2 semble avantageuse. <\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">La majeure partie du cartilage est un sel prot\u00e9ique de l\u2019acide chondro\u00eftine sulfurique (1937). Ceux d\u2019entre nous qui ont travaill\u00e9 dur pour isoler des oligosaccharides de hyaluronane de tailles d\u00e9finies ne peuvent qu\u2019admirer le <span class=\"s2\">profil de la figure 2<\/span>, qui montre la r\u00e9solution de base jusqu\u2019\u00e0 18 mers dans les fractions d\u2019une colonne d\u2019\u00e9change d\u2019ions, recueillies en 1954 sans l\u2019avantage d\u2019un collecteur de fractions (1954).<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #800080;\">Cela a conduit \u00e0 l\u2019hypoth\u00e8se que la matrice extracellulaire \u00e9tait principalement un sel prot\u00e9ique d\u2019acide chondro\u00eftine sulfurique, un concept qui a pr\u00e9valu jusqu\u2019au milieu des ann\u00e9es 1950.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">Meyer en 1958, les travaux men\u00e9s principalement dans le laboratoire de Maxwell Schubert ont r\u00e9fut\u00e9 cette hypoth\u00e8se en d\u00e9masquant la prot\u00e9ine centrale et en jetant les bases de la recherche sur les prot\u00e9oglycanes.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #800080;\">On sait depuis longtemps que la plupart des sulfates de chondro\u00eftine des tissus ne se pr\u00e9sentent pas sous forme de polysaccharides libres, mais plut\u00f4t sous forme de complexes prot\u00e9iques.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">De nombreuses contributions ont \u00e9t\u00e9 apport\u00e9es \u00e0 la litt\u00e9rature sur les complexes prot\u00e9iques, y compris les miennes en 1936, qui se sont r\u00e9v\u00e9l\u00e9es erron\u00e9es, \u00e0 savoir que le polysaccharide \u00e9tait li\u00e9 \u00e0 la prot\u00e9ine uniquement par des liaisons polaires.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">The D<span class=\"s3\">r <\/span>Schubert a entam\u00e9 certaines des \u00e9tudes les plus fondamentales sur les \u00ab complexes prot\u00e9iques du sulfate de chondro\u00eftine du cartilage \u00bb (Karl Meyer, Josiah Macy Jr. Foundation Conference 4 : <span style=\"color: #800080;\">Chondroitine Sulfates, 1958).<\/span> Alors que le sulfate de chondro\u00eftine \u00e9tait connu depuis pr\u00e8s d\u2019un si\u00e8cle, le sulfate de k\u00e9ratane restait \u00e0 d\u00e9couvrir.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\">Se tournant \u00e0 nouveau vers le tissu oculaire, cette fois-ci la corn\u00e9e, Meyer isole <span style=\"color: #800080;\">un glycosaminoglycane inconnu<\/span>. Il a d\u2019abord pens\u00e9 qu\u2019il s\u2019agissait d\u2019une forme sulfat\u00e9e de l\u2019hyaluronane. Cependant, il est apparu clairement que le partenaire sucre \u00e9tait le galactose et non l\u2019acide glucuronique, et il a propos\u00e9 le nom de <span style=\"color: #800080;\">k\u00e9ratosulfate.<\/span><\/span><\/h4>\n<h4 class=\"p3\"><span style=\"color: #0000ff;\">Trois fractions distinctes de mucopolysaccharides ont \u00e9t\u00e9 obtenues \u00e0 partir de la corn\u00e9e bovine. <\/span><\/h4>\n<h4 class=\"p3\"><span style=\"color: #0000ff;\">Elles ont \u00e9t\u00e9 identifi\u00e9es comme; (1) le sulfate de chondro\u00eftine, (2) une fraction ressemblant \u00e0 l\u2019acide hyaluronique, et (3) un mucopolysaccharide sulfat\u00e9, compos\u00e9 de quantit\u00e9s \u00e9quimolaires de glucosamine, d\u2019ac\u00e9tyle, de galactose et de sulfate, pour lequel nous proposons le nom de k\u00e9ratosulfate. <\/span><\/h4>\n<h4 class=\"p3\"><span style=\"color: #0000ff;\">Ce dernier repr\u00e9sente environ la moiti\u00e9 de la fraction mucopolysaccharidique totale de la corn\u00e9e (1953).<\/span><\/h4>\n<h4 class=\"p4\"><span style=\"color: #0000ff;\">La m\u00eame \u00e9tude a propos\u00e9 que l\u2019hyaluronane soit \u00e9galement pr\u00e9sent dans la corn\u00e9e, une conclusion bas\u00e9e sur l\u2019observation que certains des glycosaminoglycanes \u00e9taient sous-sulfat\u00e9s.<\/span><\/h4>\n<h4 class=\"p5\"><span style=\"color: #0000ff;\"><span class=\"s2\"><i>La mol\u00e9cule de k\u00e9ratosulfate. <\/i><\/span>(chondro\u00eftine, comme il s\u2019est av\u00e9r\u00e9).<\/span><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f826b5e elementor-widget elementor-widget-image\" data-id=\"f826b5e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1052\" height=\"584\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.00.png\" class=\"attachment-full size-full wp-image-22176\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.00.png 1052w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.00-300x167.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.00-1024x568.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.00-768x426.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.00-18x10.png 18w\" sizes=\"(max-width: 1052px) 100vw, 1052px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f0d717 elementor-widget elementor-widget-heading\" data-id=\"6f0d717\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">EN 1981, MEYER AVAIT RE\u00c7U DE NOMBREUSES R\u00c9COMPENSES, DONT L\u2019\u00c9LECTION \u00c0 L\u2019ACAD\u00c9MIE NATIONALE DES SCIENCES EN 1967. <br><br>SA R\u00c9PUTATION DE P\u00c8RE DE LA CHIMIE DES GLYCOSAMINOGLYCANES \u00c9TAIT FERMEMENT \u00c9TABLIE.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2fc2fc8 elementor-widget elementor-widget-text-editor\" data-id=\"2fc2fc8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"p1\"><span style=\"color: #0000ff;\">\" <i>En repensant \u00e0 ma carri\u00e8re scientifique, je me suis souvent demand\u00e9 si cela valait la peine de m\u2019accrocher avec autant de t\u00e9nacit\u00e9 \u00e0 un domaine techniquement difficile et, conceptuellement, apparemment peu excitant, alors que mes coll\u00e8gues et amis se tournaient vers des domaines plus \u00e0 la mode et plus gratifiants. <\/i><\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #0000ff;\"><span class=\"s1\"><i>Les raisons de ma pers\u00e9v\u00e9rance sont multiples : <\/i><\/span><i>parmi elles, une r\u00e9pugnance \u00e0 sauter sur un terrain d\u00e9frich\u00e9 par d\u2019autres. En outre, je me sentais engag\u00e9 dans des probl\u00e8mes tels que les fonctions biologiques des mucopolysaccharides des tissus conjonctifs, leur r\u00f4le dans la diff\u00e9renciation, dans les membranes cellulaires et dans les maladies h\u00e9r\u00e9ditaires <\/i>(Karl Meyer, National Academy of Sciences, 1967) \u00bb.<\/span><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d6411c0 elementor-widget elementor-widget-image\" data-id=\"d6411c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1990\" height=\"1088\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.17.png\" class=\"attachment-full size-full wp-image-22186\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.17.png 1990w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.17-300x164.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.17-1024x560.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.17-768x420.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.17-1536x840.png 1536w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.17-18x10.png 18w\" sizes=\"(max-width: 1990px) 100vw, 1990px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff43d41 elementor-widget elementor-widget-text-editor\" data-id=\"ff43d41\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"p1\"><span style=\"color: #0000ff;\">\u00c0 cette \u00e9poque, il est de retour au d\u00e9partement d\u2019ophtalmologie de Columbia en tant que professeur \u00e9m\u00e9rite, apr\u00e8s y \u00eatre retourn\u00e9 en 1976 \u00e0 l\u2019invitation d\u2019<span class=\"s2\">Endre Alexander Balazs <\/span>(dont nous allons \u00e9voquer le r\u00f4le majeur pour le d\u00e9veloppement des connaissances et des applications de l\u2019AH), apr\u00e8s avoir \u00e9t\u00e9 pendant neuf ans professeur de biochimie \u00e0 l\u2019universit\u00e9 de Yeshiva.<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #0000ff;\"><span class=\"s1\"><i>Endre Alexander Balazs, le biochimiste hongrois qui a relay\u00e9 en 1943 Karl Meyer pour introduire l\u2019acide hyaluronique dans la pharmacop\u00e9e humaine et animale.\u00a0<\/i><\/span><\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #0000ff;\"><span class=\"s1\">Karl Meyer a continu\u00e9 \u00e0 travailler au laboratoire pendant quelques ann\u00e9es encore, jusqu\u2019\u00e0 la fin des <\/span>ann\u00e9es 1980, avant que sa sant\u00e9 d\u00e9faillante ne l\u2019en emp\u00eache.\u00a0<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #0000ff;\">Son dernier article, publi\u00e9 en 1983, portait sur l\u2019oeil, en l\u2019occurrence une \u00e9tude des glycosaminoglycanes dans l\u2019humeur vitr\u00e9e d\u2019un poisson(1983). Karl Meyer est d\u00e9c\u00e9d\u00e9 le 18 mai 1990, \u00e0 l\u2019\u00e2ge de 90 ans. La <span class=\"s1\"><i>Society for Complex Carbohydrate<\/i><\/span>s, pr\u00e9curseur de l\u2019actuelle <span class=\"s1\"><i>Society for Glycobiology<\/i><\/span>, a cr\u00e9\u00e9 le <span class=\"s1\"><i>Karl Meyer Award for Glycoconjugate Research <\/i><\/span>en 1991, un an apr\u00e8s sa mort.<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #0000ff;\">\u00a0Karl Meyer est souvent consid\u00e9r\u00e9 comme le p\u00e8re de la recherche sur les glycosaminoglycanes, et ses contributions \u00e0 notre connaissance des structures de l\u2019hyaluronane, du sulfate de chondro\u00eftine et du sulfate de k\u00e9ratane (trois des quatre classes de glycosaminoglycanes) m\u00e9ritent certainement cette consid\u00e9ration.<\/span><\/h4>\n<h4 class=\"p1\"><span style=\"color: #0000ff;\">Il est donc tout \u00e0 fait appropri\u00e9 que la soci\u00e9t\u00e9 honore son travail et sa m\u00e9moire par le biais du prix qui porte son nom.<\/span><\/h4>\n<h4 class=\"p2\"><span style=\"color: #0000ff;\"><i>Cette biosketch de Karl Meyer est bas\u00e9e sur un poster intitul\u00e9 \u00abKarl Meyer-Discoverer of Hyaluronan\u00bb pr\u00e9sent\u00e9 en 2000 lors d\u2019une r\u00e9union internationale \u00abHyaluronan 2000\u00bb \u00e0 Wrexham, au Pays de Galles (Kennedy et al., 2002) et sur une version publi\u00e9e dans Glycobiology en 2004 pour expliquer pourquoi la \u00abGlycobiology Society\u00bb a cr\u00e9\u00e9 son prix annuel Karl Meyer pour r\u00e9compenser les meilleurs chercheurs en glycobiologie (Hascall, 2004). <\/i><\/span><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0173084 elementor-widget elementor-widget-text-editor\" data-id=\"0173084\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p>\n<p class=\"p1\"><strong><span style=\"color: #0000ff;\">REFERENCES<\/span><\/strong><\/p>\n<ol class=\"ol1\">\n<li class=\"li2\"><strong><span style=\"color: #0000ff;\">Hascall, V. C. 2004. Le prix Karl Meyer pour la recherche sur les glycoconjugu\u00e9s. Glycobiology 14:3G-6G.<\/span><\/strong><\/li>\n<li class=\"li2\"><strong><span style=\"color: #0000ff;\">Kennedy, J. F., G. O. Phillips, et P. A. Williams, eds. 2002. Hyaluronan : Volume 1-Chemical, Biochemical and Biological Aspects. Cambridge, U.K. : Woodhead Publishing.<\/span><\/strong><\/li>\n<li class=\"li2\"><strong><span style=\"color: #0000ff;\">McDonald, J., et V. C. Hascall. 2002. Hyaluronan Minireview Series. J. Biol. Chem. 277:4575-4579.<\/span><\/strong><\/li>\n<li class=\"li3\"><strong><span style=\"color: #0000ff;\">Rapport, M. M., A. Linker, et K. Meyer. 1951. L\u2019hydrolyse de l\u2019acide hyaluronique par la hyaluronidase pneumococcique. J. Biol. Chem. 192:283-291.<\/span><\/strong><\/li>\n<\/ol>\n<p>\u00a0<\/p>\n<p class=\"p5\"><strong><span style=\"color: #800080;\">SELECTED BIBLIOGRAPHY<\/span><\/strong><\/p>\n<p class=\"p6\"><strong><span style=\"color: #800080;\">The following list comprises 20 of Karl Meyer\u2019s most important publications. The first one is a one-page description of his work as a student with Otto Meyerhof. It was his second citation and his first in English. The last one is his last published work.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1927. With O. Meyerhof. The purification of the lactic acid forming enzyme of muscle. J. Physiol. 64: 16.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1934. With J. W. Palmer. The polysaccharide of the vitreous humor. J. Biol. Chem. 107: 629-34.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1937. With E. M. Smyth. On glycoproteins. VI. The preparation of chondroitinsulfuric acid. J. Biol. Chem. 119 :507-10.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1939. With E. M. Smyth and M. H. Dawson. The isolation of a mucopolysaccharide from synovial fluid. J. Biol. Chem. 128: 319-27.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1951. With M. Rapport, B. Weissmann, and A. Linker. Isolation of a crystalline disaccharide, hyalobiuronic acid, from hyaluronic acid. Nature 168: 996-7.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1953. With B. Weissmann, M. M. Rapport, and A. Linker. Isolation of the aldobionic acid of umbilical cord hyaluronic acid. J. Biol. Chem. 205: 205-11.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1953. With A. Linker, E. A. Davidson, and B. Weissmann. The mucopolysaccharides of bovine cornea. J. Biol. Chem. 205: 611-6.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1954. With B. Weissmann, P. Sampson, and A. Linker. Isolation of oligosaccharides enzymatically produced from hyaluronic acid. J. Biol. Chem. 208: 417-29.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1954. With B. Weissman. The structure of hyalobiuronic acid and of hyaluronic acid from umbilical cord. J. Am. Chem. Soc. 76:1753-1757.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1954. With A. Linker. Production of unsaturated uronides by bacterial hyaluronidases. Nature 174:1192-1193.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1954. With E. A. Davidson. Chondroitin, a new mucopolysaccharide. J. Biol. Chem. 211:605-611.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1955. With E. Davidson. Structural studies on chondroitin sulfuric acid. II. The glucuronidic linkage. J. Am. Chem. Soc. 77: 4796-8.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1956.With A. Linker and P. Hoffman. The production of unsaturated uronides by bacterial hyaluronidases. J. Biol. Chem. 219: 13-25.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1956. With P. Hoffman and A. Linker. Transglycosylation during the mixed digestion of hyaluronic acid and chondroitin sulfate by testicular hyaluronidase. J. Biol. Chem. 219: 653-63.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1957.With A. Linker and P. Hoffman. The hyaluronidase of the leech: An endogluronidase. Nature 180: 810-1.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1960. With A. Linker and P. Hoffman. The production of hyaluronate oligosaccharides by leech hyaluronidase and alkali. J. Biol. Chem. 235: 924-7.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1960. With P. Hoffman, A. Linker, and V. Lippman. The structure of chondroitin sulfate Bfrom studies with flavobacterium enzymes. J. Biol. Chem. 235: 3066-9.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1965. With B. Anderson and P. Hoffman. The O-serine linkage in peptides of chondroitin 4- or 6-sulfate. J. Biol. Chem. 240: 156-67.<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1965. With N. Seno, B. Anderson, and P. Hoffman. Variations in keratosulfates. J. Biol. Chem. 240: 1005-10.14 BIOGRAPHICAL MEMOIRS<\/span><\/strong><\/p>\n<p class=\"p7\"><strong><span style=\"color: #800080;\">1983. With G. Armand, E. Balazs, and M. Reyes. Isolation and characterization of ichthyosan from tuna vitreous. Connect. Tissue Res. 11: 21-33.15<\/span><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e13d7c elementor-widget elementor-widget-image\" data-id=\"1e13d7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"672\" height=\"1024\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.39-672x1024.png\" class=\"attachment-large size-large wp-image-22196\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.39-672x1024.png 672w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.39-197x300.png 197w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.39-768x1170.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.39-1008x1536.png 1008w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.39-8x12.png 8w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/07\/Capture-decran-2024-07-15-a-00.31.39.png 1302w\" sizes=\"(max-width: 672px) 100vw, 672px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ef3c37f e-flex e-con-boxed e-con e-parent\" data-id=\"ef3c37f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>THE STORY OF A YOUNG JEWISH DOCTOR AND BIOCHEMIST<br \/>\nGERMAN, WHO EMIGRATED TO THE USA IN 1930 TO ESCAPE<br \/>\nTHE NAZI REGIME. HE DISCOVERS ACID<br \/>\nHYALURONIC. A LONG STORY BEGINS<br \/>\n120 YEARS AGO.<\/p>","protected":false},"author":2,"featured_media":23638,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[154],"tags":[359,357],"auteur":[456],"mots-cles":[],"class_list":["post-22132","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-e-nquete","tag-lm2-2024-les-enquetes-de-lm","tag-lm2-2024-replay","auteur-karl-meyer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>LM N\u00b02\/ 2024. ACTE 1. LA SAGA DE KARL MEYER . LE D\u00c9COUVREUR DE L&#039;AH. - Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/posts\/22132\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LM N\u00b02\/ 2024. ACTE 1. LA SAGA DE KARL MEYER . LE D\u00c9COUVREUR DE L&#039;AH. - Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique\" \/>\n<meta property=\"og:description\" content=\"L\u2019\u00c9POP\u00c9E D\u2019UN JEUNE M\u00c9DECIN ET BIOCHIMISTE JUIF ALLEMAND, QUI \u00c9MIGRE AUX USA EN 1930 POUR FUIR LE R\u00c9GIME NAZI. IL VA D\u00c9COUVRIR L\u2019ACIDE HYALURONIQUE. UNE LONGUE HISTOIRE QUI COMMENCE IL Y A 120 ANS.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/\" \/>\n<meta property=\"og:site_name\" content=\"Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/looketmedecine.magazine\/\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-18T22:10:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-06T10:06:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/08\/Capture-decran-2024-08-21-a-15.22.28.png\" \/>\n\t<meta property=\"og:image:width\" content=\"338\" \/>\n\t<meta property=\"og:image:height\" content=\"318\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Albert-Claude Benhamou\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Albert-Claude Benhamou\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"16 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/\"},\"author\":{\"name\":\"Albert-Claude Benhamou\",\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/#\\\/schema\\\/person\\\/d674c704426e829b385c4dd691b8e3cc\"},\"headline\":\"LM N\u00b02\\\/ 2024. ACTE 1. LA SAGA DE KARL MEYER . LE D\u00c9COUVREUR DE L&rsquo;AH.\",\"datePublished\":\"2024-08-18T22:10:04+00:00\",\"dateModified\":\"2024-10-06T10:06:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/\"},\"wordCount\":3212,\"publisher\":{\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/looketmedecine.fr\\\/wp-content\\\/uploads\\\/2024\\\/08\\\/Capture-decran-2024-08-21-a-15.22.28.png\",\"keywords\":[\"lm2 2024 les enquetes de lm\",\"lm2 2024 replay\"],\"articleSection\":[\"Les enqu\u00eates de L&amp;M\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/\",\"url\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/\",\"name\":\"LM N\u00b02\\\/ 2024. ACTE 1. LA SAGA DE KARL MEYER . LE D\u00c9COUVREUR DE L'AH. - Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/looketmedecine.fr\\\/wp-content\\\/uploads\\\/2024\\\/08\\\/Capture-decran-2024-08-21-a-15.22.28.png\",\"datePublished\":\"2024-08-18T22:10:04+00:00\",\"dateModified\":\"2024-10-06T10:06:33+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/#primaryimage\",\"url\":\"https:\\\/\\\/looketmedecine.fr\\\/wp-content\\\/uploads\\\/2024\\\/08\\\/Capture-decran-2024-08-21-a-15.22.28.png\",\"contentUrl\":\"https:\\\/\\\/looketmedecine.fr\\\/wp-content\\\/uploads\\\/2024\\\/08\\\/Capture-decran-2024-08-21-a-15.22.28.png\",\"width\":338,\"height\":318,\"caption\":\"KARL MEYER\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/en\\\/si-la-saga-de-lah-metait-contee\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/looketmedecine.fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"LM N\u00b02\\\/ 2024. ACTE 1. LA SAGA DE KARL MEYER . LE D\u00c9COUVREUR DE L&rsquo;AH.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/#website\",\"url\":\"https:\\\/\\\/looketmedecine.fr\\\/\",\"name\":\"Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique\",\"description\":\"La sant\u00e9 esth\u00e9tique fond\u00e9e sur des preuves scientifiques\",\"publisher\":{\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/looketmedecine.fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/#organization\",\"name\":\"Looketmedecine\",\"url\":\"https:\\\/\\\/looketmedecine.fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/looketmedecine.fr\\\/wp-content\\\/uploads\\\/2020\\\/11\\\/cropped-LookMedecine_Logo_Textuel_Noir.png\",\"contentUrl\":\"https:\\\/\\\/looketmedecine.fr\\\/wp-content\\\/uploads\\\/2020\\\/11\\\/cropped-LookMedecine_Logo_Textuel_Noir.png\",\"width\":1500,\"height\":145,\"caption\":\"Looketmedecine\"},\"image\":{\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/looketmedecine.magazine\\\/\",\"https:\\\/\\\/www.instagram.com\\\/looketmedecine\\\/?hl=fr\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/looketmedecine.fr\\\/#\\\/schema\\\/person\\\/d674c704426e829b385c4dd691b8e3cc\",\"name\":\"Albert-Claude Benhamou\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f4c13b834cf55e3822893169175e3671a59788fb9e2d84d3a223c96e83a8f09e?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f4c13b834cf55e3822893169175e3671a59788fb9e2d84d3a223c96e83a8f09e?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f4c13b834cf55e3822893169175e3671a59788fb9e2d84d3a223c96e83a8f09e?s=96&d=mm&r=g\",\"caption\":\"Albert-Claude Benhamou\"},\"url\":\"https:\\\/\\\/looketmedecine.fr\\\/en\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"LM N\u00b02\/ 2024. ACTE 1. LA SAGA DE KARL MEYER . LE D\u00c9COUVREUR DE L'AH. - Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/posts\/22132","og_locale":"en_US","og_type":"article","og_title":"LM N\u00b02\/ 2024. ACTE 1. LA SAGA DE KARL MEYER . LE D\u00c9COUVREUR DE L'AH. - Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique","og_description":"L\u2019\u00c9POP\u00c9E D\u2019UN JEUNE M\u00c9DECIN ET BIOCHIMISTE JUIF ALLEMAND, QUI \u00c9MIGRE AUX USA EN 1930 POUR FUIR LE R\u00c9GIME NAZI. IL VA D\u00c9COUVRIR L\u2019ACIDE HYALURONIQUE. UNE LONGUE HISTOIRE QUI COMMENCE IL Y A 120 ANS.","og_url":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/","og_site_name":"Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique","article_publisher":"https:\/\/www.facebook.com\/looketmedecine.magazine\/","article_published_time":"2024-08-18T22:10:04+00:00","article_modified_time":"2024-10-06T10:06:33+00:00","og_image":[{"width":338,"height":318,"url":"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/08\/Capture-decran-2024-08-21-a-15.22.28.png","type":"image\/png"}],"author":"Albert-Claude Benhamou","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Albert-Claude Benhamou","Est. reading time":"16 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/#article","isPartOf":{"@id":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/"},"author":{"name":"Albert-Claude Benhamou","@id":"https:\/\/looketmedecine.fr\/#\/schema\/person\/d674c704426e829b385c4dd691b8e3cc"},"headline":"LM N\u00b02\/ 2024. ACTE 1. LA SAGA DE KARL MEYER . LE D\u00c9COUVREUR DE L&rsquo;AH.","datePublished":"2024-08-18T22:10:04+00:00","dateModified":"2024-10-06T10:06:33+00:00","mainEntityOfPage":{"@id":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/"},"wordCount":3212,"publisher":{"@id":"https:\/\/looketmedecine.fr\/#organization"},"image":{"@id":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/#primaryimage"},"thumbnailUrl":"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/08\/Capture-decran-2024-08-21-a-15.22.28.png","keywords":["lm2 2024 les enquetes de lm","lm2 2024 replay"],"articleSection":["Les enqu\u00eates de L&amp;M"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/","url":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/","name":"LM N\u00b02\/ 2024. ACTE 1. LA SAGA DE KARL MEYER . LE D\u00c9COUVREUR DE L'AH. - Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique","isPartOf":{"@id":"https:\/\/looketmedecine.fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/#primaryimage"},"image":{"@id":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/#primaryimage"},"thumbnailUrl":"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/08\/Capture-decran-2024-08-21-a-15.22.28.png","datePublished":"2024-08-18T22:10:04+00:00","dateModified":"2024-10-06T10:06:33+00:00","breadcrumb":{"@id":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/#primaryimage","url":"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/08\/Capture-decran-2024-08-21-a-15.22.28.png","contentUrl":"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/08\/Capture-decran-2024-08-21-a-15.22.28.png","width":338,"height":318,"caption":"KARL MEYER"},{"@type":"BreadcrumbList","@id":"https:\/\/looketmedecine.fr\/en\/si-la-saga-de-lah-metait-contee\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/looketmedecine.fr\/"},{"@type":"ListItem","position":2,"name":"LM N\u00b02\/ 2024. ACTE 1. LA SAGA DE KARL MEYER . LE D\u00c9COUVREUR DE L&rsquo;AH."}]},{"@type":"WebSite","@id":"https:\/\/looketmedecine.fr\/#website","url":"https:\/\/looketmedecine.fr\/","name":"N\u00b01 French magazine for research in aesthetic health","description":"Aesthetic health based on scientific evidence","publisher":{"@id":"https:\/\/looketmedecine.fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/looketmedecine.fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/looketmedecine.fr\/#organization","name":"Looketmedicine","url":"https:\/\/looketmedecine.fr\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/looketmedecine.fr\/#\/schema\/logo\/image\/","url":"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2020\/11\/cropped-LookMedecine_Logo_Textuel_Noir.png","contentUrl":"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2020\/11\/cropped-LookMedecine_Logo_Textuel_Noir.png","width":1500,"height":145,"caption":"Looketmedecine"},"image":{"@id":"https:\/\/looketmedecine.fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/looketmedecine.magazine\/","https:\/\/www.instagram.com\/looketmedecine\/?hl=fr"]},{"@type":"Person","@id":"https:\/\/looketmedecine.fr\/#\/schema\/person\/d674c704426e829b385c4dd691b8e3cc","name":"Albert-Claude Benhamou","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/f4c13b834cf55e3822893169175e3671a59788fb9e2d84d3a223c96e83a8f09e?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/f4c13b834cf55e3822893169175e3671a59788fb9e2d84d3a223c96e83a8f09e?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/f4c13b834cf55e3822893169175e3671a59788fb9e2d84d3a223c96e83a8f09e?s=96&d=mm&r=g","caption":"Albert-Claude Benhamou"},"url":"https:\/\/looketmedecine.fr\/en"}]}},"_links":{"self":[{"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/posts\/22132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/comments?post=22132"}],"version-history":[{"count":69,"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/posts\/22132\/revisions"}],"predecessor-version":[{"id":24077,"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/posts\/22132\/revisions\/24077"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/media\/23638"}],"wp:attachment":[{"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/media?parent=22132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/categories?post=22132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/tags?post=22132"},{"taxonomy":"auteur","embeddable":true,"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/auteur?post=22132"},{"taxonomy":"mots-cles","embeddable":true,"href":"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/mots-cles?post=22132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}