{"id":20466,"date":"2024-05-26T19:54:53","date_gmt":"2024-05-26T17:54:53","guid":{"rendered":"https:\/\/looketmedecine.fr\/?p=20466"},"modified":"2024-10-05T23:56:30","modified_gmt":"2024-10-05T21:56:30","slug":"correction-des-changements-lies-a-lage-avec-du-prp-active-par-de-la-thrombine-autologue-et-de-lacide-hyaluronique-en-combinaison-avec-un","status":"publish","type":"post","link":"https:\/\/looketmedecine.fr\/en\/correction-des-changements-lies-a-lage-avec-du-prp-active-par-de-la-thrombine-autologue-et-de-lacide-hyaluronique-en-combinaison-avec-un\/","title":{"rendered":"LM N\u00b01\/ 2024. CORRECTION OF AGE-RELATED CHANGES WITH AUTOLOGOUS THROMBIN-ACTIVATED PRP AND HYALURONIC ACID IN COMBINATION WITH RF-MICRONEEDLING EQUIPMENT.                                                                     Inna SHARYPOVA, MD, PhD. Andrey ALENICHEV, MD, PhD.\u00a0"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"20466\" class=\"elementor elementor-20466\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2bc67b32 e-con-full e-flex e-con e-parent\" data-id=\"2bc67b32\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-708f8b89 elementor-widget elementor-widget-text-editor\" data-id=\"708f8b89\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\n<p>\u00a0\u00a0<\/p>\n\n\n\n<p><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f4c9abc elementor-widget elementor-widget-heading\" data-id=\"f4c9abc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">LM SURVEY ON ANTI-AGING THERAPEUTIC PROCEDURES<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2abd563 elementor-widget elementor-widget-image\" data-id=\"2abd563\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"279\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-05-26-a-19.56.21-300x279.png\" class=\"attachment-medium size-medium wp-image-20468\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-05-26-a-19.56.21-300x279.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-05-26-a-19.56.21-13x12.png 13w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-05-26-a-19.56.21.png 592w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1abf8ad elementor-widget elementor-widget-heading\" data-id=\"1abf8ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">CORRECTION OF AGE-RELATED CHANGES WITH AUTOLOGOUS THROMBIN-ACTIVATED PLATELET-RICH PLASMA AND HYALURONIC ACID IN COMBINATION WITH MICRONEEDLING RF EQUIPMENT <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c8a0d0 elementor-widget elementor-widget-heading\" data-id=\"1c8a0d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Inna SHARYPOVA, M.D., Ph.D.\nAndrey ALENICHEV, M.D., Ph.D.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27ece80 elementor-widget elementor-widget-text-editor\" data-id=\"27ece80\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 style=\"text-align: center;\"><strong><em>Dermatologists, Kristel Medical, Milan<\/em><\/strong><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2af1341 elementor-widget elementor-widget-text-editor\" data-id=\"2af1341\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4><span style=\"color: #008000;\"><strong>THE RELEVANCE OF INFORMATION<\/strong><\/span><\/h4>\n<p><span style=\"color: #000000;\"><strong>Today, dermatologists and cosmetologists have a wide arsenal of tools at their disposal to treat age-related skin changes, including various medical equipment, injection methods and cosmeceuticals. Age-related skin changes are a task that cannot be solved using state-of-the-art technologies alone.<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\"><strong>This is why methods that combine different mechanisms acting on skin cells and the extracellular dermal matrix are highly relevant.<\/strong><\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>The main aim of any combination is to improve the correction effect and reduce adverse reactions.<\/strong><\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>To achieve this, it is necessary to improve the condition of the skin in many ways: from surface characteristics to profound changes in cellular function and tissue structure.<\/strong><\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>We can achieve these goals by reinforcing treatment protocols with methods that support repair processes by improving microcirculation and tissue regeneration.<\/strong><\/span><\/p>\n<h4><span style=\"color: #008000;\"><strong>EQUIPMENT-BASED METHODS<\/strong><\/span><\/h4>\n<p><span style=\"color: #000000;\"><strong>Today, a number of physical methods can be used to correct the signs of skin ageing: laser radiation, focused ultrasound, radiofrequency electric currents, broadband light, etc.<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\"><strong>The medical devices used in cosmetology induce controlled micro-traumas that disrupt the physiological balance of skin tissue and trigger the restructuring processes that follow.<\/strong><\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>For example, the mechanisms of fractional radiofrequency (RF) microneedling are mainly based on the thermal effect and aseptic inflammation at the site of controlled microtrauma.<\/strong><\/span><\/li>\n<li><span style=\"color: #000000;\"><strong>Their appearance is directly linked to the frequency of the alternating current passing through the skin - the lower the RF, the more pronounced the effect.<\/strong><\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>Compared with non-ablative fractional photothermolysis, fractional radiofrequency microneedling delivers energy to deeper layers of the skin.<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cc33f50 elementor-widget elementor-widget-text-editor\" data-id=\"cc33f50\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4><span style=\"color: #008000;\"><strong>PRP AND AH IN COMBINATION WITH FRACTIONAL RADIOFREQUENCY MICRONEEDLING<\/strong><\/span><\/h4>\n<ul>\n<li><strong>Under the influence of the physical factors underlying methods based on fractional radiofrequency Microneedling, a greater number of cells in the epidermis, dermis and subcutaneous tissue move into an active state. This leads to structural and functional improvements.<\/strong><\/li>\n<li><strong>The desired effect of the device's use is only possible when there is an optimal balance between the stress factor, represented by the device's action, and the tissue's ability to adapt...<\/strong><\/li>\n<li><strong>To enhance and optimize the skin's ability to regenerate and replenish itself, biological injection methods are used, in particular autologous platelet-rich plasma (PRP) therapy.<\/strong><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<h4><span style=\"color: #008000;\"><strong>The effectiveness of PRP therapy relies on the triggering of reparative and trophic processes activated by various paracrine factors present in platelets.<\/strong><\/span><\/h4>\n<ul>\n<li><strong>PRP has a strong healing and regenerative potential, as it is a concentrate of the main bioactive substances involved in the various stages of the healing process.<\/strong><\/li>\n<li><strong>The effect of PRP is due to degranulation of platelet alpha granules, which contain glycoproteins and growth factors including platelet growth factor, transforming growth factor beta, fibroblast growth factor, vascular endothelial growth factor and epidermal growth factor.<\/strong><\/li>\n<li><strong>In particular, the biological \"cocktail\" secreted by platelets has the ideal physiological proportion of growth factors. On contact with a surface different in structure from the vascular endothelium, and under the action of thrombin, platelets become activated, transformed and produce pseudopods that bind them to the fibrin network.<\/strong><\/li>\n<li><strong>Under the action of growth factors, dermal fibroblasts synthesize collagen, elastin and a non-fibrous matrix that strengthen and lift the skin.<\/strong><\/li>\n<li><strong>In addition, new capillaries form (angiogenesis) and the epidermis renews itself. To achieve a significant clinical effect, it is essential to have a sufficient number of viable platelets which, after being activated in the tissue by the patient's own thrombin, release growth factors and other bioactive substances into the surrounding intercellular space.<\/strong><\/li>\n<\/ul>\n<h4><span style=\"color: #008000;\"><strong>Essential conditions must be met for PRP preparations:<\/strong><\/span><\/h4>\n<ul>\n<li><strong>Platelet concentration must be 1.5 to 2.5 times higher than in blood. In particular, concentrations 2.5 to 3.0 times higher than physiological values lead to mutual inhibition of platelets and a marked reduction in the release of growth factors;<\/strong><\/li>\n<li><strong>the absence of heparin, which blocks the ability of platelets to aggregate on fibrin, thus blocking the physiological process of activation and release of growth factors;<\/strong><\/li>\n<li><strong>cells must not be mechanically destroyed during preparation, as growth factors only become biologically active when preformed by crossing intact, functionally active platelet membranes;<\/strong><\/li>\n<li><strong>a minimum number of granulocytes, which have pro-inflammatory activity;<\/strong><\/li>\n<li><strong>absence of red blood cells ;<\/strong><\/li>\n<li><strong>presence of monocytes, which enhance the efficacy of the preparation by reinforcing non-specific immunity.<\/strong><\/li>\n<\/ul>\n<p><strong>Injectable hyaluronic acid (HA) preparations are well known to cosmetologists.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-804b57a elementor-widget elementor-widget-text-editor\" data-id=\"804b57a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4><span style=\"color: #008000;\"><strong>In the skin, HA molecules over 500 kDa create the conditions for cell migration and proliferation, and maintain homeostatic equilibrium. <\/strong><strong>Today, we also have a combined approach for intradermal injections: Cellular MatrixTM.<\/strong><\/span><\/h4>\n<ul>\n<li><strong>RegenLab's patented medical device contains the patient's own autologous PRP and a certain form of hyaluronic acid.<\/strong><\/li>\n<li><strong>The non-cross-linked hyaluronic acid contained in the tube acts as a scaffold-like structural element, while PRP has a restorative and regenerative effect. The presence of hyaluronic acid exactly at the moment of fibrin polymerization enables the formation of three-dimensional structures in which platelets are dispersed.<\/strong><\/li>\n<li><strong>These 3D structures are colonized by fibroblasts, enabling increased synthesis of extracellular matrix components and organized dermal reconstruction.<\/strong><\/li>\n<li><strong>When the preparation containing the patient's autologous PRP and HA is injected into the target tissues, a biologically enriched network is formed, a matrix that facilitates cell migration and proliferation, improves tissue hydrodynamics and ensures the distribution of trace elements, metabolites and hormones.<\/strong><\/li>\n<\/ul>\n<h4><strong><span style=\"color: #008000;\">MATERIALS AND METHODS<\/span><\/strong><\/h4>\n<p><strong>For the treatment of signs of skin ageing, particularly in the face and neck areas, we use a protocol that combines PRP injections and radiofrequency microneedling.<\/strong><\/p>\n<p><strong>For PRP therapy, we apply two RegenLab medical devices to each treatment:<\/strong><\/p>\n<ol>\n<li><strong>The RegenLab kit Plus device with additional activation of PRP with autologous thrombin serum (ATS) to form an autologous PRP gel used to fill wrinkles and improve facial contours.<\/strong><\/li>\n<li><strong>Device Cellular MatrixTM (CM), which combines PRP and 2 ml of non-cross-linked hyaluronic acid (HA) with 2 % in a single tube. It enables a biologically identical material to be prepared in a single step for immediate use in a completely closed sterile system (<a href=\"#_bookmark0\">Figure 1<\/a>).<\/strong><\/li>\n<\/ol>\n<p><strong>The use of CM leads to a physiologically-determined activation of regeneration processes under the action of platelet growth factors and interleukins, while the hyaluronic acid contained in the preparation optimizes tissue hydration, helping to fill in wrinkles and folds.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-64da253 elementor-widget elementor-widget-image\" data-id=\"64da253\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"435\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.21.10.png\" class=\"attachment-large size-large wp-image-21437\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.21.10.png 1018w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.21.10-300x163.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.21.10-768x418.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.21.10-18x10.png 18w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a5a843 elementor-widget elementor-widget-text-editor\" data-id=\"1a5a843\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 style=\"text-align: center;\"><strong><em>Figure 1. <\/em><em>The stages <\/em><em>cell matrix preparation.<\/em><\/strong><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0a8a06c elementor-widget elementor-widget-image\" data-id=\"0a8a06c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"499\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.22.15.png\" class=\"attachment-large size-large wp-image-21438\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.22.15.png 1010w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.22.15-300x187.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.22.15-768x479.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.22.15-18x12.png 18w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3782138 elementor-widget elementor-widget-text-editor\" data-id=\"3782138\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 style=\"text-align: center;\"><em>Figure 2. <\/em><em>Injection diagram.<\/em><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb663a3 elementor-widget elementor-widget-text-editor\" data-id=\"bb663a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>The overall strategy of PRP injections for the aesthetic correction of age-related changes is specifically aimed at increasing dermal elasticity and turgor. It is advisable to inject the preparation using the linear \"filler-like\" technique with 30-32G needles.<\/strong><\/p>\n<ul>\n<li><strong>PRP-HA is administered intradermally using the retrograde linear technique for facial soft tissue lifting.<\/strong><\/li>\n<li><strong>It should be noted that in certain areas of the skin, the bolus technique is preferable (<a href=\"#_bookmark1\">Figure 2<\/a>).<\/strong><\/li>\n<li><strong>Radiofrequency therapy was performed using a Pologen RF device (from Lumenis) designed for minimally invasive fractionated bipolar RF therapy.<\/strong><\/li>\n<li><strong>The RF device's energy has a direct effect (heating) on the epidermis and dermis at a depth of 0.6 to 1.5 mm.<\/strong><\/li>\n<li><strong>Non-insulated microelectrodes deliver lossless RF energy directly to the selected zone, where water evaporates from the microthermal zone.<\/strong><\/li>\n<\/ul>\n<p><strong>This stimulates the physiological healing process, as well as collagen and elastin synthesis.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12d764d elementor-widget elementor-widget-image\" data-id=\"12d764d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"754\" height=\"810\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.24.37.png\" class=\"attachment-full size-full wp-image-21442\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.24.37.png 754w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.24.37-279x300.png 279w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.24.37-11x12.png 11w\" sizes=\"(max-width: 754px) 100vw, 754px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbacdbc elementor-widget elementor-widget-image\" data-id=\"dbacdbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"572\" height=\"534\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.24.43.png\" class=\"attachment-large size-large wp-image-21443\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.24.43.png 572w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.24.43-300x280.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.24.43-13x12.png 13w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1877cb9 elementor-widget elementor-widget-image\" data-id=\"1877cb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"503\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.26.14.png\" class=\"attachment-large size-large wp-image-21447\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.26.14.png 1002w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.26.14-300x189.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.26.14-768x483.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.26.14-18x12.png 18w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ea44bc elementor-widget elementor-widget-text-editor\" data-id=\"4ea44bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 style=\"text-align: center;\"><em>Figure 3. <\/em><em>Effect of RF microneedles on tissue.<\/em><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1db5cff elementor-widget elementor-widget-text-editor\" data-id=\"1db5cff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>For skin rejuvenation of the face and body, the treatment consisted of three treatment cycles, performed at one-month intervals according to the following scheme: the RF micro-needling facelift treatment was performed, followed by an injection of RegenLab PRP and cellular matrix one week later.<\/strong><\/p>\n<p><strong>After a three-week break, this cycle was repeated.<\/strong><\/p>\n<p><strong>The recommended monthly intervals should be observed between device-based and injection-based treatments.<\/strong><\/p>\n<p><strong>It is important to note that PRP and cellular matrix injections were performed shortly after radiofrequency stimulation of the dermis.<\/strong><\/p>\n<p><strong>This contributed to rapid skin restoration after treatment-induced skin trauma, as well as improved neo-collagenogenesis and restored microcirculation.<\/strong><\/p>\n<h2><strong>\" Inclusion criteria<\/strong><\/h2>\n<p><strong>Gender - female and male, age - 40-70 years, informed consent to be included in the study, no hypersensitivity to HA and no contraindications to radiofrequency therapy.<\/strong><\/p>\n<h2><strong>\" Exclusion criteria<\/strong><\/h2>\n<p><strong>Active skin diseases, acute herpes and other skin infections, exacerbation of general infectious diseases or chronic somatic diseases, mental illness, use of antidepressants or drugs affecting the central nervous system, epilepsy, cancer.<\/strong><\/p>\n<h4><strong>We observed 30 patients with signs of facial skin ageing, aged between 40 and 70, who underwent combination therapy in accordance with the developed protocol.<\/strong><\/h4>\n<p><strong>To assess stratum corneum hydration before and after treatment, corneometry was performed using the CM 825 Corneometer.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a2d6f08 elementor-widget elementor-widget-image\" data-id=\"a2d6f08\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"690\" height=\"618\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.29.09.png\" class=\"attachment-large size-large wp-image-21451\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.29.09.png 690w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.29.09-300x269.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.29.09-13x12.png 13w\" sizes=\"(max-width: 690px) 100vw, 690px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e093eb elementor-widget elementor-widget-text-editor\" data-id=\"5e093eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5><strong>Transepidermal water loss (TEWL) was assessed before and after treatment using the Tewameter TM300 vaporimeter.<\/strong><\/h5>\n<ul>\n<li><strong>The effectiveness of aesthetic correction of facial skin was assessed using visual analog scales, photographs and a quality-of-life study.<\/strong><\/li>\n<li><strong>Results were compared in two age groups: under 49 (n =1 5) and over 50 (n = 15).<\/strong><\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-815e772 elementor-widget elementor-widget-image\" data-id=\"815e772\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"646\" height=\"716\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.30.21.png\" class=\"attachment-large size-large wp-image-21455\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.30.21.png 646w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.30.21-271x300.png 271w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.30.21-11x12.png 11w\" sizes=\"(max-width: 646px) 100vw, 646px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec7f59f elementor-widget elementor-widget-text-editor\" data-id=\"ec7f59f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4><span style=\"color: #008000;\"><strong>RESULTS<\/strong><\/span><\/h4>\n<p><strong>Comparative evaluation of skin functional parameters (hydration and TEWL) showed promising results for combined therapy with cellular matrix and radiofrequency lifting (<a href=\"#_bookmark2\">Table 1<\/a>).<\/strong><\/p>\n<ul>\n<li><strong>In fact, the hydration of the stratum corneum after the <\/strong><strong>combined therapy was 1.7 times higher in patients under 49 and 2.1 times higher in patients over 50, while TEWL decreased 2.8 times in the under 49 group and 2.2 times in the over 50 group.<\/strong><\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-270ff7d elementor-widget elementor-widget-text-editor\" data-id=\"270ff7d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table width=\"945\">\n<tbody>\n<tr>\n<td colspan=\"6\" width=\"945\">\n<p><span style=\"color: #000000;\"><b>Matrix<\/b> <b>cellular<\/b> <b>+<\/b> <b>RF<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"121\">\n<p><span style=\"color: #000000;\"><b>Parameter<\/b><b>s<\/b><\/span><\/p>\n<\/td>\n<td colspan=\"2\" width=\"352\">\n<p><strong><span style=\"color: #000000;\">Under 49<\/span><\/strong><\/p>\n<\/td>\n<td width=\"121\">\n<p><strong><span style=\"color: #000000;\">P-value<\/span><\/strong><\/p>\n<\/td>\n<td colspan=\"2\" width=\"352\">\n<p><span style=\"color: #000000;\"><b>More than 50 <\/b><b>years<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"121\">\n<p><span style=\"color: #000000;\"><b>\u00a0<\/b><\/span><\/p>\n<\/td>\n<td width=\"176\">\n<p><strong><span style=\"color: #000000;\">before treatment<\/span><\/strong><\/p>\n<\/td>\n<td width=\"176\">\n<p><strong><span style=\"color: #000000;\">after treatment<\/span><\/strong><\/p>\n<\/td>\n<td width=\"121\">\n<p>\u00a0<\/p>\n<\/td>\n<td width=\"176\">\n<p><strong><span style=\"color: #000000;\">before treatment<\/span><\/strong><\/p>\n<\/td>\n<td width=\"176\">\n<p><span style=\"color: #000000;\"><b>after<\/b><b> treatment<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"121\">\n<p><span style=\"color: #000000;\"><b>Hydratatio<\/b><b>n<\/b><\/span><\/p>\n<p><span style=\"color: #000000;\"><b>TEW<\/b><b>L<\/b><\/span><\/p>\n<\/td>\n<td width=\"176\">\n<p><span style=\"color: #000000;\"><b>51,1 \u00b1 <\/b><b>2,8<\/b><\/span><\/p>\n<p><span style=\"color: #000000;\"><b>23,7 \u00b1 <\/b><b>1,6<\/b><\/span><\/p>\n<\/td>\n<td width=\"176\">\n<p><span style=\"color: #000000;\"><b>85,8 \u00b1 <\/b><b>3,6<\/b><\/span><\/p>\n<p><span style=\"color: #000000;\"><b>8,5 \u00b1 <\/b><b>1,9<\/b><\/span><\/p>\n<\/td>\n<td width=\"121\">\n<p><span style=\"color: #000000;\"><b>P &lt; <\/b><b>0,001<\/b><\/span><\/p>\n<p><span style=\"color: #000000;\"><b>P<\/b> <b>&lt; <\/b><b>0,01<\/b><\/span><\/p>\n<\/td>\n<td width=\"176\">\n<p><span style=\"color: #000000;\"><b>38,7 \u00b1 <\/b><b>3,4<\/b><\/span><\/p>\n<p><span style=\"color: #000000;\"><b>28,1 \u00b1 <\/b><b>2,6<\/b><\/span><\/p>\n<\/td>\n<td width=\"176\">\n<p><span style=\"color: #000000;\"><b>79,9 \u00b1 <\/b><b>4,2<\/b><\/span><\/p>\n<p><span style=\"color: #000000;\"><b>12,9 \u00b1 <\/b><b>1,7<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fae6d31 elementor-widget elementor-widget-text-editor\" data-id=\"fae6d31\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5 style=\"text-align: left;\"><strong><em>Table 1.\u00a0\u00a0\u00a0 <\/em><em>Skin hydration and loss of skin elasticity with RegenLab's fractional radiofrequency microneedling, cell matrix and PRP combination therapy.<\/em><\/strong><\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2992521 elementor-widget elementor-widget-image\" data-id=\"2992521\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"327\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.36.35-1024x419.png\" class=\"attachment-large size-large wp-image-21465\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.36.35-1024x419.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.36.35-300x123.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.36.35-768x314.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.36.35-18x7.png 18w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.36.35.png 1262w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-80a26f8 elementor-widget elementor-widget-text-editor\" data-id=\"80a26f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5><strong><em>Figure 4. <\/em><em>Reduction in clinical signs of skin chrono-aging after treatment with the combined method, according to the VAS index (qualitative characteristics of the skin and severity of wrinkles) in patients under 49.<\/em><\/strong><\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7607152 elementor-widget elementor-widget-image\" data-id=\"7607152\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"289\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.37.29-1024x370.png\" class=\"attachment-large size-large wp-image-21466\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.37.29-1024x370.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.37.29-300x108.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.37.29-768x278.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.37.29-18x7.png 18w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.37.29.png 1262w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-796888e elementor-widget elementor-widget-text-editor\" data-id=\"796888e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5><strong><em>Figure 5. <\/em><em>Reduction in clinical signs of skin chrono-aging after treatment with the combined method, according to the VAS index (qualitative characteristics of the skin and severity of wrinkles) in patients over 50.<\/em><\/strong><\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-08a5b4e elementor-widget elementor-widget-text-editor\" data-id=\"08a5b4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Assessment using visual analog scales showed a reduction in the main signs of chrono-aging in both groups (<a href=\"#_bookmark3\">Figure 4<\/a> and <a href=\"#_bookmark4\">Figure 5<\/a>).<\/strong><\/p>\n<ul>\n<li><strong>Improved skin quality and reduced severity of mimic and gravitational wrinkles contributed to an overall improvement in patients' quality of life.<\/strong><\/li>\n<li><strong>On average, the DLQI improved by 79.9 % in patients under 49: from 14.5 \u00b1 0.7 to 2.9 \u00b1 0.8 (p &lt; 0.01) (<a href=\"#_bookmark4\">Figure 5<\/a>), and 75.4 % in patients over 50: from 16.2 \u00b1 0.9 to <\/strong><strong>4.0 \u00b1 0.5 points (p&lt;0.01) (<a href=\"#_bookmark5\">Figure 6<\/a>).<\/strong><\/li>\n<li><strong>Another indicator was evaluated in the study - \"satisfaction\" (efficacy, comfort and safety of treatment); it reflects the patient's opinion based on comparison of expected and received effects in relation to other methods used for similar indications. The overall patient assessment was as follows: 90 % of patients, regardless of age, rated the efficacy and comfort of the combined method as good\/very good (<a href=\"#_bookmark6\">Figure 7<\/a>).<\/strong><\/li>\n<li><strong>Dermatoscopic and photographic data also confirmed the clinical efficacy of the combined therapeutic protocol.<\/strong><\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d475d52 elementor-widget elementor-widget-image\" data-id=\"d475d52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"416\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.39.34-1024x533.png\" class=\"attachment-large size-large wp-image-21470\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.39.34-1024x533.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.39.34-300x156.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.39.34-768x400.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.39.34-18x9.png 18w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.39.34.png 1060w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a30e7b3 elementor-widget elementor-widget-text-editor\" data-id=\"a30e7b3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Figure 6. <\/em><em>Mean Dermatological Quality of Life Index (DLQI) scores after treatment with the combined method to correct signs of aging of facial skin (y-axis: median values, at p &lt; 0.01 according to the Mann-Whitney criterion).<\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aaf124c elementor-widget elementor-widget-image\" data-id=\"aaf124c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"322\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.41.26-1024x412.png\" class=\"attachment-large size-large wp-image-21471\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.41.26-1024x412.png 1024w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.41.26-300x121.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.41.26-768x309.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.41.26-18x7.png 18w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.41.26.png 1268w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-992f218 elementor-widget elementor-widget-text-editor\" data-id=\"992f218\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Figure 7. <\/em><em>Data from the patient questionnaire on the efficacy\/comfort\/safety of the combined method for correcting signs of ageing of facial skin.<\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e61dfd5 elementor-widget elementor-widget-heading\" data-id=\"e61dfd5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Clinical examples of the use of the combined method (radiofrequency facelift and cellular matrix) to correct age-related skin changes.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-86bb38d elementor-widget elementor-widget-gallery\" data-id=\"86bb38d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;gallery_layout&quot;:&quot;justified&quot;,&quot;ideal_row_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:496,&quot;sizes&quot;:[]},&quot;link_to&quot;:&quot;custom&quot;,&quot;lazyload&quot;:&quot;yes&quot;,&quot;ideal_row_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:150,&quot;sizes&quot;:[]},&quot;ideal_row_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:150,&quot;sizes&quot;:[]},&quot;gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;url&quot;:{&quot;url&quot;:&quot;&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;,&quot;custom_attributes&quot;:&quot;&quot;},&quot;overlay_background&quot;:&quot;yes&quot;,&quot;content_hover_animation&quot;:&quot;fade-in&quot;}\" data-widget_type=\"gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-gallery__container\">\n\t\t\t\t\t\t\t<a class=\"e-gallery-item elementor-gallery-item elementor-animated-content\">\n\t\t\t\t\t<div class=\"e-gallery-image elementor-gallery-item__image\" data-thumbnail=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.42.33-256x300.png\" data-width=\"256\" data-height=\"300\" aria-label=\"\" role=\"img\" ><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-gallery-item__overlay\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<a class=\"e-gallery-item elementor-gallery-item elementor-animated-content\">\n\t\t\t\t\t<div class=\"e-gallery-image elementor-gallery-item__image\" data-thumbnail=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.42.47-260x300.png\" data-width=\"260\" data-height=\"300\" aria-label=\"\" role=\"img\" ><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-gallery-item__overlay\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a6b552 elementor-widget elementor-widget-text-editor\" data-id=\"2a6b552\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><strong><em>Before and after combined treatment, patient E. 44 years old<\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb0bc33 elementor-widget elementor-widget-gallery\" data-id=\"fb0bc33\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;gallery_layout&quot;:&quot;justified&quot;,&quot;ideal_row_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:500,&quot;sizes&quot;:[]},&quot;gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:100,&quot;sizes&quot;:[]},&quot;lazyload&quot;:&quot;yes&quot;,&quot;ideal_row_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:150,&quot;sizes&quot;:[]},&quot;ideal_row_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:150,&quot;sizes&quot;:[]},&quot;gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;link_to&quot;:&quot;file&quot;,&quot;overlay_background&quot;:&quot;yes&quot;,&quot;content_hover_animation&quot;:&quot;fade-in&quot;}\" data-widget_type=\"gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-gallery__container\">\n\t\t\t\t\t\t\t<a class=\"e-gallery-item elementor-gallery-item elementor-animated-content\" href=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.45.18.png\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"fb0bc33\" data-elementor-lightbox-title=\"Capture d\u2019e\u0301cran 2024-06-08 a\u0300 22.45.18\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjE0NzQsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDVcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDYtMDgtYS0yMi40NS4xOC5wbmciLCJzbGlkZXNob3ciOiJmYjBiYzMzIn0%3D\">\n\t\t\t\t\t<div class=\"e-gallery-image elementor-gallery-item__image\" data-thumbnail=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.45.18-269x300.png\" data-width=\"269\" data-height=\"300\" aria-label=\"\" role=\"img\" ><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-gallery-item__overlay\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<a class=\"e-gallery-item elementor-gallery-item elementor-animated-content\" href=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.45.36.png\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"fb0bc33\" data-elementor-lightbox-title=\"Capture d\u2019e\u0301cran 2024-06-08 a\u0300 22.45.36\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjE0NzUsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMDVcL0NhcHR1cmUtZGVjcmFuLTIwMjQtMDYtMDgtYS0yMi40NS4zNi5wbmciLCJzbGlkZXNob3ciOiJmYjBiYzMzIn0%3D\">\n\t\t\t\t\t<div class=\"e-gallery-image elementor-gallery-item__image\" data-thumbnail=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/Capture-decran-2024-06-08-a-22.45.36-266x300.png\" data-width=\"266\" data-height=\"300\" aria-label=\"\" role=\"img\" ><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-gallery-item__overlay\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d7824e elementor-widget elementor-widget-text-editor\" data-id=\"2d7824e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><strong><em>Before and after combined treatment, patient E. 53 years old<\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-96942d4 elementor-widget elementor-widget-text-editor\" data-id=\"96942d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4><span style=\"color: #008000;\"><strong>CONCLUSION<\/strong><\/span><\/h4>\n<p><strong>The protocol we have developed for combined therapy using bipolar RF micro-needling facelift and injection of RegenLabTM PRP and Cellular MatrixTM is a highly effective method for correcting age-related skin changes, resulting in dermal volumization and skin renewal.<\/strong><\/p>\n<ul>\n<li><strong>We recommend that this treatment strategy be widely used in clinical practice.<\/strong><\/li>\n<li><strong>In addition, PRP can be combined with other equipment used in cosmetology, such as laser, light and ultrasound.<\/strong><\/li>\n<li><strong>Cellular MatrixTM increases the skin's ability to adapt and repair itself.<\/strong><\/li>\n<\/ul>\n<h4><strong>Significant rejuvenation effects in most patients last up to 1.5-2 years.<\/strong><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e88c8b9 elementor-widget elementor-widget-text-editor\" data-id=\"e88c8b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #800080;\">REFERENCES<\/span><\/h2>\n<ol>\n<li><span style=\"color: #800080;\">Franco W, Kotare A, Ronan Sj and Hyperthermic injury to adipocyte cells by selective heating of subcutaneous fat with a novel radiofrequency device: feasibility studies. Lasers Surg Med. 2010. - \u0421. 361-70.<\/span><\/li>\n<\/ol>\n<ol start=\"2\">\n<li><span style=\"color: #800080;\">Sadick NS, Makino Selective electro-thermolysis in aesthetic medicine: a review. Lasers Surg Med. 2004.- C.91-7.<\/span><\/li>\n<li><span style=\"color: #800080;\">Belenky I, Margulis A, Elman M, Bar-Yosef U, Paun Exploring channeling optimized radiofrequency energy: a review of radiofrequency history and applications in esthetic fields. Adv Ther. 2012 Mar; 29(3): 249-66.<\/span><\/li>\n<li><span style=\"color: #800080;\">Carruthers Radiofrequency resurfacing: technique and clinical review. Facial Plast Surg Clin N Am 2001. - C. 311-9.<\/span><\/li>\n<li><span style=\"color: #800080;\">Weiner SF. Radiofrequency Microneedling: Overview of Technology, Advantages, Differences in Devices, Studies, and Indications. Facial Plast Surg Clin North Am. 2019 Aug; 27(3): 291-303.<\/span><\/li>\n<li><span style=\"color: #800080;\">Friedman Dj, Gilead The use of hybrid radiofrequency device for the treatment of rhytides and lax skin. Dermatol Surg 2007. - 543-51.<\/span><\/li>\n<li><span style=\"color: #800080;\">Redaelli A, Romano D, Marciano A. Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. Drugs Dermatol. - 2010; 9:466-72.<\/span><\/li>\n<li><span style=\"color: #800080;\">Rappl M. et al. Effect of platelet-rich plasma gel in a physiologically relevant platelet concentration on wounds in persons with spinal cord injury. Int Wound J 2011; 8:18.7-195.<\/span><\/li>\n<li><span style=\"color: #800080;\">Smith J. D., Melhem M. E. et al. Improved growth factor directed vascularization into fibrin constructs through inclusion of additional extracellular molecules. Microvasc Res. 2007. 73(2): 84-94.<\/span><\/li>\n<li><span style=\"color: #800080;\">al, Effects of PlateletRich Plasma on Intestinal Anastomotic Healing in Rats: PRP Concentration is a Key Factor. J Surg Res. 2012 Apr; 173 (2):258-66.<\/span><\/li>\n<li><span style=\"color: #800080;\">Turzi, PRP Standardization and Cell Therapy.. Biobridge Foundation, Lausagne 2018.<\/span><\/li>\n<li><span style=\"color: #800080;\">Girish KS, Kemparaju The magic glue hyaluronan and its eraser hyaluronidase: a biological overview. Life Sci. 2007 May 1 80(21):1921-43. Epub 2007 Mar 6.<\/span><\/li>\n<li><span style=\"color: #800080;\">Stern R, Maibach HI. Hyaluronan in skin: aspects of aging and its pharmacologic modulation. Clin Dermatol. 2008 Mar- Apr; 26(2):106-22. doi: 10.1016\/j.clindermatol.2007.09.013.<\/span><\/li>\n<li><span style=\"color: #800080;\">Oh JH, Kim YK, Jung JY, Shin JE, Kim KH, Cho KH, Eun HC, Chung Intrinsic aging- and photoaging-dependent level changes of glycosaminoglycans and their correlation with water content in human skin. J Dermatol Sci. 2011 Jun; 62(3):192-201. doi: 10.1016\/j.jdermsci.2011.02.007. Epub 2011 Mar 2.<\/span><\/li>\n<\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1305bf elementor-widget elementor-widget-image\" data-id=\"e1305bf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1359\" height=\"1754\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/082_091_Sharypova-enquete_page-0010.jpg\" class=\"attachment-full size-full wp-image-20484\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/082_091_Sharypova-enquete_page-0010.jpg 1359w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/082_091_Sharypova-enquete_page-0010-232x300.jpg 232w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/082_091_Sharypova-enquete_page-0010-793x1024.jpg 793w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/082_091_Sharypova-enquete_page-0010-768x991.jpg 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/082_091_Sharypova-enquete_page-0010-1190x1536.jpg 1190w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2024\/05\/082_091_Sharypova-enquete_page-0010-9x12.jpg 9w\" sizes=\"(max-width: 1359px) 100vw, 1359px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7074d45 e-flex e-con-boxed e-con e-parent\" data-id=\"7074d45\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u00a0\u00a0 ENQU\u00caTE DE LM SUR LES PROC\u00c9DURES TH\u00c9RAPEUTIQUES ANTI-\u00c2GE CORRECTION DES CHANGEMENTS LI\u00c9S \u00c0 L\u2019\u00c2GE AVEC DU PLASMA RICHE EN PLAQUETTES ACTIV\u00c9 PAR DE LA THROMBINE AUTOLOGUE ET DE L\u2019ACIDE HYALURONIQUE EN COMBINAISON AVEC UN \u00c9QUIPEMENT DE RF MICRONEEDLING Inna SHARYPOVA, M.D., Ph.D. Andrey ALENICHEV, M.D., Ph.D. Dermatologues, Kristel Medical, Milan LA PERTINENCE DE L\u2019INFORMATION [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":20468,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[154,156],"tags":[343,344,345],"auteur":[462,463],"mots-cles":[],"class_list":["post-20466","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-e-nquete","category-procedures-therapeutiques-fr","tag-lm1-2024-replay","tag-lm1-2024-theme-enquete","tag-lm1-2024-theme-procedures-therapeutiques","auteur-andrey-alenichev","auteur-inna-sharypova"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>LM N\u00b01\/ 2024. CORRECTION DES CHANGEMENTS LI\u00c9S \u00c0 L\u2019\u00c2GE AVEC DU PRP ACTIV\u00c9 PAR LA THROMBINE AUTOLOGUE ET L\u2019ACIDE HYALURONIQUE EN COMBINAISON AVEC UN \u00c9QUIPEMENT DE RF-MICRONEEDLING.                                   Inna SHARYPOVA,MD., PhD.\u00a0Andrey ALENICHEV, MD., PhD.\u00a0 - Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique<\/title>\n<meta name=\"description\" content=\"Le protocole que nous avons mis au point pour la th\u00e9rapie combin\u00e9e utilisant le lifting par micro-aiguilletage RF bipolaire et l\u2019injection de PRP RegenLabTM et de Cellular MatrixTM est une m\u00e9thode tr\u00e8s efficace pour corriger les changements cutan\u00e9s li\u00e9s \u00e0 l\u2019\u00e2ge, ce qui entra\u00eene une volumisation du derme et un renouvellement de la peau.Nous recommandons que cette strat\u00e9gie de traitement soit largement utilis\u00e9e dans la pratique clinique. En outre, le PRP peut \u00eatre combin\u00e9 avec d\u2019autres \u00e9quipements utilis\u00e9s en cosm\u00e9tologie, tels que le laser, la lumi\u00e8re et les ultrasons. La pr\u00e9paration Cellular MatrixTM permet d\u2019augmenter les capacit\u00e9s d\u2019adaptation et de r\u00e9paration de la peau.Les effets de rajeunissement significatifs chez la plupart des patients durent jusqu\u2019\u00e0 1,5-2 ans.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/looketmedecine.fr\/en\/wp-json\/wp\/v2\/posts\/20466\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LM N\u00b01\/ 2024. CORRECTION DES CHANGEMENTS LI\u00c9S \u00c0 L\u2019\u00c2GE AVEC DU PRP ACTIV\u00c9 PAR LA THROMBINE AUTOLOGUE ET L\u2019ACIDE HYALURONIQUE EN COMBINAISON AVEC UN \u00c9QUIPEMENT DE RF-MICRONEEDLING.                                   Inna SHARYPOVA,MD., PhD.\u00a0Andrey ALENICHEV, MD., PhD.\u00a0 - Revue fran\u00e7aise N\u00b01 pour la recherche en sant\u00e9 esth\u00e9tique\" \/>\n<meta property=\"og:description\" content=\"Le protocole que nous avons mis au point pour la th\u00e9rapie combin\u00e9e utilisant le lifting par micro-aiguilletage RF bipolaire et l\u2019injection de PRP RegenLabTM et de Cellular MatrixTM est une m\u00e9thode tr\u00e8s efficace pour corriger les changements cutan\u00e9s li\u00e9s \u00e0 l\u2019\u00e2ge, ce qui entra\u00eene une volumisation du derme et un renouvellement de la peau.Nous recommandons que cette strat\u00e9gie de traitement soit largement utilis\u00e9e dans la pratique clinique. En outre, le PRP peut \u00eatre combin\u00e9 avec d\u2019autres \u00e9quipements utilis\u00e9s en cosm\u00e9tologie, tels que le laser, la lumi\u00e8re et les ultrasons. 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