{"id":13419,"date":"2022-10-10T20:26:52","date_gmt":"2022-10-10T18:26:52","guid":{"rendered":"https:\/\/looketmedecine.fr\/?p=13419"},"modified":"2024-10-05T23:22:53","modified_gmt":"2024-10-05T21:22:53","slug":"lm3-model","status":"publish","type":"post","link":"https:\/\/looketmedecine.fr\/en\/lm3-model\/","title":{"rendered":"LM N\u00b0 2\/ 2022. Everything you need to know. Methodology and best practices for integrating \"regenerative medicine\" in compliance with regulations. Dr Nicola Beneduce MD"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"13419\" class=\"elementor elementor-13419\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e8fa00c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e8fa00c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cab699f\" data-id=\"cab699f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-15979e7 elementor-widget elementor-widget-text-editor\" data-id=\"15979e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1 style=\"text-align: right;\"><span style=\"color: #0000ff;\"><strong>Another look <\/strong><\/span><\/h1><h2 style=\"text-align: right;\">\u00a0<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c61303 elementor-widget elementor-widget-heading\" data-id=\"6c61303\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Methodology and good practices\n\nto integrate \"regenerative medicine\n\nin compliance with the regulations.<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-140c581 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"140c581\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0974032\" data-id=\"0974032\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bd5155a elementor-widget elementor-widget-heading\" data-id=\"bd5155a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Dr. Nicola Beneduce, MD\n\nDepartment of plastic and maxillofacial surgery. AP-HP Paris-Est Cr\u00e9teil\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b74789 elementor-widget elementor-widget-image\" data-id=\"1b74789\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"246\" height=\"300\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-17.27.43-246x300.png\" class=\"attachment-medium size-medium wp-image-13788\" alt=\"Dr. NICOLA BENEDUCE MD\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-17.27.43-246x300.png 246w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-17.27.43-838x1024.png 838w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-17.27.43-768x938.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-17.27.43-1257x1536.png 1257w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-17.27.43-1676x2048.png 1676w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-17.27.43-10x12.png 10w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-17.27.43.png 2048w\" sizes=\"(max-width: 246px) 100vw, 246px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0e43bc9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0e43bc9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e8b3176\" data-id=\"e8b3176\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-811b886 elementor-widget elementor-widget-heading\" data-id=\"811b886\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">INTRODUCTION.\n\nPRP - Platelet Rich Plasma <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c42451e elementor-widget elementor-widget-text-editor\" data-id=\"c42451e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\"><span style=\"color: #0000ff;\"><strong>PRP - Platelet Rich Plasma <\/strong><strong>&#8211;<\/strong> <strong>is a blood-derived biological product characterized by a high concentration of growth factors. <\/strong><\/span><\/span><\/p><ul><li><span style=\"color: #000000;\">The <em>Platelet-Rich Plasma<\/em>PRP, from which the acronym PRP is derived, is used therapeutically because of its unique ability to stimulate and facilitate tissue regeneration. <\/span><\/li><li><span style=\"color: #000000;\">PRP has long been used in the medical fields of cardiac surgery, oral surgery, orthopedics, gynecology and facial plastic surgery, and continues to develop as a versatile therapy in dermatology.<\/span><\/li><li><span style=\"color: #000000;\"><strong><span style=\"color: #0000ff;\">PDGF (Platelet Derived Growth Factor):<\/span> i<\/strong>It has mitogenic and angiogenic action with up-regulation of other growth factors, stimulates fibroblasts and osteoblasts, induces cell differentiation and is a catalyst for the effects of growth factors on other cells such as macrophages. It also stimulates chemotaxis and its reticular structure facilitates the diapedesis of macrophages and fibroblasts. 2.<\/span><\/li><\/ul><ul><li><span style=\"color: #000000;\"><strong><span style=\"color: #0000ff;\">THE EGF<\/span> (epidermal growth factor):<\/strong> It has the ability to induce proliferation and differentiation of mesenchymal and epithelial cells and also promotes angiogenesis. 3.<\/span><\/li><li><span style=\"color: #000000;\"><span style=\"color: #0000ff;\"><strong>TGF (transforming growth factor):<\/strong> <\/span>stimulates fibroblasts and pre-osteoblasts, inhibits epithelial and endothelial cells and is an important mediator of extracellular matrix formation. 4.<\/span><\/li><li><span style=\"color: #000000;\"><span style=\"color: #0000ff;\"><strong>VEGF (Vascular Endothelial Growth Factor):<\/strong><\/span> stimulates monocyte migration through the endothelial layers and is one of the most important angiogenic factors. It induces an increase in the permeability of endothelial cells to proteins and other molecules; this permeability leads to the extravasation of fibrinogen and the formation of fibrin, which in turn induces the migration of fibroblasts.<\/span><\/li><li><span style=\"color: #000000;\"><span style=\"color: #0000ff;\"><strong>FGF (Fibroblasts Growth Factor):<\/strong><\/span> They are powerful regulators of cell proliferation and fibroblast differentiation. It plays an important role in normal development and wound repair. <\/span>It stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal and endodermal origin.<\/li><li><strong><span style=\"color: #000000;\"><span style=\"color: #0000ff;\">These cells include: fibroblasts, endothelial cells, osteocytes.<\/span> <\/span><\/strong><span style=\"color: #000000;\">They also play an important role in the formation of new endothelia. <\/span><\/li><li><strong><span style=\"color: #000000;\">Platelets<\/span><span style=\"color: #000000;\"> are therefore comparable to cell reservoirs that release numerous growth factors that stimulate the reproduction of stem cells, mesenchymal cells, fibroblasts, osteoblasts and endothelial cells. <\/span><\/strong><\/li><li><span style=\"color: #000000;\">They also release other types of granules containing ADP, ATP, calcium ions, histamine, serotonin and dopamine that play a complex role in tissue modulation and regeneration. <\/span><\/li><li><span style=\"color: #000000;\">Finally, they still contain lysosomal granules that may secrete various enzymes whose precise role in the healing process is not yet well understood. <\/span><\/li><li><span style=\"color: #0000ff;\"><strong>Over the years, attention to PRI has grown to over 3000 articles in the last 5 years.<\/strong><\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1425f4c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1425f4c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f387c31\" data-id=\"f387c31\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5c1e837 elementor-widget elementor-widget-heading\" data-id=\"5c1e837\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PREPARATION OF THE PRP<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1826a36 elementor-widget elementor-widget-text-editor\" data-id=\"1826a36\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #0000ff;\"><strong>There are two different ways to prepare PRP: open-loop and closed-loop.<\/strong><\/span><\/p><p><span style=\"color: #0000ff;\"><strong>The open loop<\/strong><\/span> i<span style=\"color: #000000;\">The use of unapproved kits, using conventional blood collection instruments, exposes the product to a high risk of contamination. <\/span><\/p><p><span style=\"color: #0000ff;\"><strong>Approved closed-loop kits, on the other hand, eliminate this risk and also make preparation easier and more reliable. <\/strong><\/span><span style=\"color: #000000;\">Although there is no clear consensus, the recommendation of the European institutions is to use approved closed-loop kits.<\/span><\/p><p><span style=\"color: #800080;\">The preparation of PRP involves the collection of autologous venous blood (i.e., the patient's own), which is then centrifuged. The patient's blood is drawn, collected and centrifuged at different speeds until it separates into three layers: platelet-poor plasma (PPP), platelet-rich plasma (PRP) and red blood cells (RBC). The material with the highest specific gravity (PRP) will be deposited at the bottom of the tube and removed for use.<\/span><\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7e1ecad elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7e1ecad\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ba3ac16\" data-id=\"ba3ac16\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-819ce91 elementor-widget elementor-widget-heading\" data-id=\"819ce91\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">REGULATIONS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-170d653 elementor-widget elementor-widget-text-editor\" data-id=\"170d653\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\"><strong><span style=\"color: #0000ff;\">Human autologous PRP should be considered a blood product.<\/span> <\/strong><\/span><\/p><p><span style=\"color: #000000;\">In order to better understand the context of the current European rules, it is necessary to differentiate between blood products for topical use and those used in cell therapy, which involve complex bioprocessing techniques for therapeutic cells. All rules have a common goal: <\/span><\/p><ul><li><span style=\"color: #000000;\">ensure the voluntary donation of a blood product;<\/span><\/li><li><span style=\"color: #000000;\"> self-sufficiency in blood, blood products and plasma derivatives; <\/span><\/li><li><span style=\"color: #000000;\">ensure the health of donors and recipients; <\/span><\/li><li><span style=\"color: #000000;\">the quality and safety of transfusion medicine procedures and products. <\/span><\/li><\/ul><p><span style=\"color: #0000ff;\"><strong>\u00a0<\/strong><\/span><\/p><p><span style=\"color: #0000ff;\"><strong>The preparation of autologous platelet concentrates is regulated by article L. 1221-8 of the public health code.<\/strong><\/span><\/p><p><span style=\"color: #0000ff;\"><strong>It is also authorized, pursuant to Article L. 1243-2, to withdraw and use autologous blood for therapeutic purposes within the framework of a single medical intervention without being stored or prepared within an organization or establishment. <\/strong><\/span><\/p><ul><li>This means that the procedure can be performed not only in a hospital setting, but also in your own practice.<\/li><\/ul><p><span style=\"color: #ff0000;\"><strong>The law therefore limits the use of PRP to treatments with a therapeutic purpose. <\/strong><\/span><\/p><ul><li><span style=\"color: #0000ff;\"><strong>The prohibition on the use of CPAs for cosmetic purposes was reiterated in a ruling by the Conseil d'Etat dated November 4, 2015.<\/strong><\/span><\/li><li><span style=\"color: #0000ff;\"><strong>The ANSM recalled in a statement published on January 10, 2018 that the use of APCs is prohibited in France. <\/strong><\/span><\/li><\/ul><p><span style=\"color: #ff0000;\"><strong>It is therefore the objective of the intervention (therapeutic or aesthetic) that determines the applicable regulations. <\/strong><\/span><\/p><ul><li><span style=\"color: #000000;\">It is therefore up to the physician to determine the right indication. The most frequent and obvious example is certainly the treatment of alopecia.<\/span><\/li><li>In this case, it is the physician's duty and interest, before proposing a PRP treatment, to make a complete assessment in order to clinically frame the patient in a meticulous way and to certify at the same time the functional character of the proposed treatment.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cd397bc elementor-widget elementor-widget-image\" data-id=\"cd397bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.17.15.png\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e8143fc elementor-widget elementor-widget-heading\" data-id=\"e8143fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">REGENKIT A-PRP <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-163b734 elementor-widget elementor-widget-image\" data-id=\"163b734\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"572\" height=\"644\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.17.22.png\" class=\"attachment-medium_large size-medium_large wp-image-13662\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.17.22.png 572w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.17.22-266x300.png 266w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.17.22-11x12.png 11w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-60ad91b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"60ad91b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-261fbac\" data-id=\"261fbac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2d4535a elementor-widget elementor-widget-heading\" data-id=\"2d4535a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">FEATURES OF RegenPRP\u00ae TECHNOLOGY<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f21fb0 elementor-widget elementor-widget-text-editor\" data-id=\"9f21fb0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><span style=\"color: #800080;\">Standardized preparation independent of the operator<\/span><\/li><li><span style=\"color: #800080;\">Low volume of blood required<\/span><\/li><li><span style=\"color: #800080;\">Closed system, no contact with the outside<\/span><\/li><li><span style=\"color: #800080;\">Mechanical separation of PRP after 5 minutes centrifugation using a biologically inert thixotropic gel<\/span><\/li><li><span style=\"color: #800080;\">Reversible anticoagulation with pharmaceutical grade sodium citrate solution at pH 7<\/span><\/li><li><span style=\"color: #800080;\">Fast learning curve and ease of use<\/span><\/li><li><span style=\"color: #800080;\">Operationally and clinically effective process<\/span><\/li><li><span style=\"color: #800080;\">Facilitates and streamlines daily practice<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-081164b elementor-widget elementor-widget-heading\" data-id=\"081164b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">BIOLOGICAL CHARACTERISTICS <\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b087a1e elementor-widget elementor-widget-text-editor\" data-id=\"b087a1e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><span style=\"color: #800080;\"><strong>Standardized and easily reproducible PRP<br \/><\/strong>RegenLab's specific gel separation technology ensures minimal variability<\/span><\/li><li><span style=\"color: #800080;\"><strong>Platelet recovery &gt; 80 %<\/strong><\/span><\/li><li><span style=\"color: #800080;\"><strong>High quality of the wafers<br \/><\/strong>Viable and functional platelets<\/span><\/li><li><span style=\"color: #800080;\"><strong>Complete plasma recovery<br \/><\/strong>No loss of plasma growth factors and fibrinogen<\/span><\/li><li><span style=\"color: #800080;\"><strong>Leukocyte-poor PRP<br \/><\/strong>Depletion ~ 96.7 % of pro-inflammatory granulocytes, leaving mainly lymphocytes and monocytes<\/span><\/li><li><span style=\"color: #800080;\"><strong>Elimination of almost all red blood cells<br \/><\/strong>Depletion of ~ 99.7 % in erythrocytes<\/span><\/li><\/ul><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-afcfd72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"afcfd72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7471369\" data-id=\"7471369\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5e5fdd3 elementor-widget elementor-widget-heading\" data-id=\"5e5fdd3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">INDICATIONS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef0849e elementor-widget elementor-widget-heading\" data-id=\"ef0849e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">ANDROGENIC ALOPECIA<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-37c78ba elementor-widget elementor-widget-text-editor\" data-id=\"37c78ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\">In the literature, we find many works on the treatment of alopecia with PRP that help us answer patients' questions. <\/span><\/p><p><span style=\"color: #0000ff;\"><strong>The most common one is certainly whether PRP can increase hair density. The answer is: yes, by 10 to 20 %. PRP slows down hair loss, as well as increases hair thickness.<\/strong><\/span><\/p><p><strong><span style=\"color: #0000ff;\">What we cannot do, however, and what must be clearly explained to our patients, is the creation of new hair follicles.<\/span><\/strong><\/p><p><span style=\"color: #000000;\">PRP should not be considered an alternative to hair transplantation, although it is often used as an adjuvant treatment in the postoperative period to maintain the result.<\/span><\/p><p><span style=\"color: #0000ff;\"><strong>Not all patients with androgenetic alopecia can benefit from PRP treatment, but only those in Norwood stage I - II or III, due to the ineffectiveness of the product when injected into a hairless area.<\/strong><\/span><\/p><p><span style=\"color: #000000;\"><span style=\"color: #0000ff;\"><strong>The technique:\u00a0<\/strong> <\/span><\/span><\/p><ul><li><span style=\"color: #000000;\">It consists in inoculating in a subdermal plane, where the hair bulb is located, 0.1 ml per cm2. <\/span><\/li><li><span style=\"color: #000000;\">Regarding the choice of material, <\/span><ul><li><span style=\"color: #000000;\">we prefer to use a 1 ml syringe, which allows us greater precision; <\/span><\/li><li><span style=\"color: #000000;\">for the needle, we follow the theory of \"the smaller the better\", thus opting for a 32G\/ 34G needle. <\/span><\/li><\/ul><\/li><li><span style=\"color: #000000;\">The goal, given that between 100 and 200 injections are performed per treatment, is to ensure that the patient suffers as little pain as possible and that bleeding is minimized. <\/span><\/li><li><span style=\"color: #000000;\">Some physicians prefer the use of the gun, which allows for a faster and more precise inoculation. <\/span><\/li><li><span style=\"color: #000000;\">This is because the gun is set to a fixed depth at which the device releases the PRP.<\/span><\/li><\/ul><p><strong><span style=\"color: #0000ff;\">To prevent hair loss, it is recommended to inject at a depth of 4 mm, in order to reach the hair bulbs directly. In cases where the patient has a bad scalp, a double injection plane is used instead, deep (4 mm) and shallower (2 mm). Initially, one session per month is planned for three months, followed by a maintenance treatment every three months.<\/span><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-03806d8 elementor-widget elementor-widget-image-gallery\" data-id=\"03806d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-1' class='gallery galleryid-13419 gallery-columns-2 gallery-size-full'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"03806d8\" data-elementor-lightbox-title=\"Capture d\u2019e\u0301cran 2022-10-14 a\u0300 11.32.11\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTM2NzcsInVybCI6Imh0dHBzOlwvXC9sb29rZXRtZWRlY2luZS5mclwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyMlwvMTBcL0NhcHR1cmUtZGVcdTAzMDFjcmFuLTIwMjItMTAtMTQtYVx1MDMwMC0xMS4zMi4xMS5wbmciLCJzbGlkZXNob3ciOiIwMzgwNmQ4In0%3D\" href='https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.32.11.png'><img decoding=\"async\" width=\"932\" height=\"654\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.32.11.png\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.32.11.png 932w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.32.11-300x211.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.32.11-768x539.png 768w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.32.11-18x12.png 18w\" sizes=\"(max-width: 932px) 100vw, 932px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b7331f elementor-widget elementor-widget-heading\" data-id=\"5b7331f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">COLORED CIRNES<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ca0324 elementor-widget elementor-widget-text-editor\" data-id=\"0ca0324\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #0000ff;\"><strong>A less common but very popular indication, especially for women, is the treatment of dark circles.<\/strong><\/span><\/p><ul><li><span style=\"color: #800080;\">In this case, 3 sessions of PRP are performed at 1 month intervals by injecting 1 ml on each side in the dermal and subdermal plane.<\/span><\/li><li><span style=\"color: #800080;\">The results are maintained by two procedures each year.<\/span><\/li><\/ul><p><span style=\"color: #0000ff;\"><strong>The results are satisfactory and without risk. A combination of peeling or laser treatment may be indicated.<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-865d57c elementor-widget elementor-widget-image-gallery\" data-id=\"865d57c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1619a37 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1619a37\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d95bc51\" data-id=\"d95bc51\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fefeb92 elementor-widget elementor-widget-heading\" data-id=\"fefeb92\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">KELOID SCARS\n\n<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6deef55 elementor-widget elementor-widget-text-editor\" data-id=\"6deef55\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #0000ff;\"><strong>Excellent results have also been obtained in the treatment of keloid scars, refractory to corticosteroid treatment and surgery, by combining PRP and surgery.<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a0cb5b7 elementor-widget elementor-widget-heading\" data-id=\"a0cb5b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">COMPLICATIONS<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-109a7eb elementor-widget elementor-widget-text-editor\" data-id=\"109a7eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #800080;\"><strong>Complications associated with this type of treatment, if the proper injection techniques are used, are extremely rare.<\/strong><\/span><\/p><p><span style=\"color: #800080;\"><strong>More common are side effects such as pain, erythema, swelling and, in the case of scalp treatment, headaches, for which scalp massages twice a day in the week following treatment should be planned.<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-519fbae elementor-widget elementor-widget-heading\" data-id=\"519fbae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">RegenKit\u00ae - Surgery<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b296d5a elementor-widget elementor-widget-image\" data-id=\"b296d5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.43.10.png\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8552c02 elementor-widget elementor-widget-text-editor\" data-id=\"8552c02\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #0000ff;\"><strong>With this kit, we can combine autologous thrombin with PRP. <\/strong><strong>By combining 1 ml of thrombin with 10 ml of PRP, a gel product is obtained that is useful in many applications. <\/strong><\/span><\/p><p><span style=\"color: #800080;\">Indeed, it has a role of biological dressing with an indication of use in patients with delayed healing, or to increase the probability of taking a skin graft.<\/span><\/p><p><span style=\"color: #800080;\">By some surgeons, it has been proposed and used as a filler to treat dark circles, while exploiting its regenerative and filling capabilities, being an extremely soft and malleable product.<\/span><\/p><p><span style=\"color: #0000ff;\"><strong>Its composition also allows it to be used as a surgical glue, a trick long known by our digestive surgeon colleagues, who use it widely in digestive anastomoses.<\/strong><\/span><\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbee112 elementor-widget elementor-widget-heading\" data-id=\"dbee112\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Cellular Matrix <\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db70b23 elementor-widget elementor-widget-text-editor\" data-id=\"db70b23\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #0000ff;\"><strong>Cellular Matrix\u00ae tubes allow the preparation of<a style=\"color: #0000ff;\" href=\"https:\/\/www.regenlab.com\/fr\/products\/regenkit-a-prp\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\"> of autologous platelet-rich plasma (RegenPRP<\/a>\u00ae)<a style=\"color: #0000ff;\" href=\"https:\/\/www.regenlab.com\/fr\/products\/regenkit-a-prp\/\" target=\"_blank\" rel=\"noopener noreferrer nofollow\"> partner<\/a> to a non-crosslinked Hyaluronic Acid (HA) in a closed system.<\/strong><\/span><\/p><p><span style=\"color: #ff0000;\"><strong>Cellular Matrix\u00ae technology combines the synergistic effects of RegenPRP\u00ae and Hyaluronic Acid (HA).<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-590c674 elementor-widget elementor-widget-image\" data-id=\"590c674\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.45.37.png\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6f9f89 elementor-widget elementor-widget-image\" data-id=\"f6f9f89\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2022\/10\/Capture-de\u0301cran-2022-10-14-a\u0300-11.46.15.png\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f68f76 elementor-widget elementor-widget-text-editor\" data-id=\"7f68f76\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #0000ff;\"><strong>Contains 2 ml of 20 mg\/ml concentrated non-cross-linked HA (40 mg in total).\u00a0\u00a0<\/strong><\/span><strong style=\"color: #0000ff; font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: 1rem;\">HA is produced by bacterial fermentation (free of animal proteins).<\/strong><\/p><p><span style=\"color: #0000ff;\"><strong>The presence of a separating gel inside ensures that the hyaluronic acid and PRP quota is not contaminated, so that the injected product is as pure as possible.<\/strong><\/span><\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89fae42 elementor-widget elementor-widget-text-editor\" data-id=\"89fae42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\"><strong><span style=\"color: #800080;\">An excellent product for facial mesotherapy, it can be applied with the topping technique or with a dermaroller.<\/span><\/strong> <\/span><\/p><ul><li><span style=\"color: #000000;\">Also in this case, it is important to remember the need to frame the patient from a clinical point of view in order to establish the right indication, such as the treatment of acne sequelae.<\/span><\/li><\/ul><p><span style=\"color: #800080;\"><strong>This kit has a wide range of use in the gynecological field, which allows it to be used in the office thanks to its approval.<\/strong><\/span><\/p><p><span style=\"color: #800080;\"><strong>Two pathological conditions benefit from treatment with PRP enriched with hyaluronic acid:\u00a0<\/strong><\/span><\/p><p><span style=\"color: #800080;\"><strong>1. Postmenopausal genitourinary syndrome <\/strong><\/span><\/p><p><span style=\"color: #800080;\"><strong>2. Vulvovaginal atrophy in women<\/strong> <strong>with a history of breast cancer:<\/strong> <\/span><\/p><ul><li><span style=\"color: #000000;\">Indeed, approximately 55-75 % of women with breast cancer have been found to have vulvovaginal atrophy related to estrogen deficiency and chemotherapy treatment. <\/span><\/li><li><span style=\"color: #000000;\">Due to these biological causes and psychological distress related to body image, a decrease in the quality of sexual life has been recorded in these patients.<\/span><\/li><li>It has also been observed that more than 30 % of patients do not complete hormonal treatment, which is often due to the side effects of the treatment itself, thus putting themselves at a higher risk of recurrence.<\/li><li>The procedure involves the topical application of an anesthetic gel and the administration of Kalynox to make the procedure as painless as possible.<\/li><\/ul><p><span style=\"color: #800080;\"><strong>3. Episiotomy scars are another indication in the gynecological field with a clear improvement in terms of aesthetics and function.<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e98efeb elementor-widget elementor-widget-image\" data-id=\"e98efeb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"552\" height=\"246\" src=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2021\/12\/Capture-de\u0301cran-2022-10-02-a\u0300-19.04.09.png\" class=\"attachment-large size-large wp-image-13195\" alt=\"\" srcset=\"https:\/\/looketmedecine.fr\/wp-content\/uploads\/2021\/12\/Capture-de\u0301cran-2022-10-02-a\u0300-19.04.09.png 552w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2021\/12\/Capture-de\u0301cran-2022-10-02-a\u0300-19.04.09-300x134.png 300w, https:\/\/looketmedecine.fr\/wp-content\/uploads\/2021\/12\/Capture-de\u0301cran-2022-10-02-a\u0300-19.04.09-18x8.png 18w\" sizes=\"(max-width: 552px) 100vw, 552px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Un autre regard \u00a0 M\u00e9thodologie et bonne pratiques pour int\u00e9grer la \u201cm\u00e9decine r\u00e9g\u00e9n\u00e9rative\u201d en conformit\u00e9 avec la r\u00e9glementation. Dr Nicola Beneduce, MD Service de chirurgie plastique et maxillo-faciale. AP-HP Paris-Est Cr\u00e9teil INTRODUCTION. Le PRP &#8211; Plasma Riche en Plaquettes Le PRP &#8211; Plasma riche en plaquettes &#8211; est un produit biologique d\u00e9riv\u00e9 du sang caract\u00e9ris\u00e9 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":13788,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[291,290],"auteur":[426],"mots-cles":[],"class_list":["post-13419","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tout-ce-que-vous-voulez-savoir","tag-lm3-tout-ce-que-vous-voulez-savoir","tag-replay-lm3","auteur-nicola-beneduce"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>LM N\u00b0 2\/ 2022. 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