hyaluronic acid

Hyaluronic acid:
from endogenous molecules to injectable gels

Denis Couchourel, PhD

Scientific and Medical Director of VIVACY Laboratories 

Hyaluronic acid is an endogenous molecule essential to extracellular matrices, with remarkable properties that are exploited by the body in specific compartments (vitreous humor, joint cavity, etc.).
It is also a biologically active molecule involved in numerous signaling processes.
It is highly conserved across species, which has enabled us to develop human applications using bacterial production systems that are therefore reliable and reproducible.
Among these uses, aesthetic medicine is at the forefront, since it is in this specialty that the challenges for manufacturers are the most demanding.
Indeed, the injected tissues are histologically very diverse, the level of anatomical and physiological complexity of the face is important, and the tolerance to side effects is very low.
Thus, the rheological behavior of the gels had to be further developed and refined by the manufacturers to constantly strive for the best possible bio-integration while aiming at the best possible clinical performance.